Evidence map›Paper›PMID 32580942›Full record

ArticleCancer immunology research2020

In Human Visualization of Ibrutinib-Induced CLL Compartment Shift.

Marius E Mayerhoefer, Alexander Haug, Ulrich Jäger, Verena Pichler, Sarah Pfaff, Hans-Jürgen Wester, Marcus Hacker, Lukas Kazianka, Philipp B Staber

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer immunology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Frontiers in oncology · 2026
    Article
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  3. Article
  4. Review
  5. Article
  6. The Role of [Cancers · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Marius E MayerhoeferDivision of General and Pediatric Radiology, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Alexander HaugDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-8308-6174
Ulrich JägerDivision of Hematology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-9826-1062
Verena PichlerDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Sarah PfaffDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Hans-Jürgen WesterPharmaceutical Radiochemistry, Technical University of Munich, Garching, Germany.
Marcus HackerDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Lukas KaziankaDivision of Hematology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Philipp B StaberDivision of Hematology, Department of Medicine I, Medical University of Vienna, Vienna, Austria. philipp.staber@meduniwien.ac.at.
Medical University of Vienna · ATChristian Doppler Laboratory for Thermoelectricity · ATMemorial Sloan Kettering Cancer Center · USTechnical University of Munich · DE

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Bruton tyrosine kinase inhibitor ibrutinib is effective in treating chronic lymphocytic leukemia (CLL). However, after ibrutinib treatment initiation, patients frequently experience an increase of CLL blood cell count. This phenomenon in clinical practice is thought to reflect a "compartment shift" of CLL cells from lymph nodes to the peripheral blood, but the actual shifting has not yet been demonstrated. Using [

Indexed as

AdenineAgammaglobulinaemia Tyrosine KinaseBone MarrowCoordination ComplexesGallium RadioisotopesHumansLeukemia, Lymphocytic, Chronic, B-CellLymph NodesPeptides, CyclicPiperidinesProtein Kinase InhibitorsReceptors, CXCR4Signal TransductionSpleen68Ga-pentixaforAdenineAgammaglobulinaemia Tyrosine KinaseBTK protein, humanCoordination ComplexesCXCR4 protein, humanGallium RadioisotopesibrutinibPeptides, CyclicPiperidinesProtein Kinase InhibitorsReceptors, CXCR4

Identifiers

PMID32580942
PMCPMC8373313
OpenAlexW3037532091

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.