Evidence map›Paper›PMID 32580940›Full record

ArticleBiology open2020

Specificity, redundancy and dosage thresholds among

Jessica Sam, Emily J Mercer, Ingrid Torregroza, Kelly M Banks, Todd Evans

Open access · goldAbstract read
In one paragraph

Article in Biology open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. An animal model recapitulates human hepatic diseases associated withProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. From Stripes to a Beating Heart: Early Cardiac Development in Zebrafish.Journal of cardiovascular development and disease · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jessica SamDepartment of Surgery, Weill Cornell Medicine, New York, NY 10065, USA.
Emily J MercerDepartment of Surgery, Weill Cornell Medicine, New York, NY 10065, USA.
Ingrid TorregrozaDepartment of Surgery, Weill Cornell Medicine, New York, NY 10065, USA.
Kelly M BanksDepartment of Surgery, Weill Cornell Medicine, New York, NY 10065, USA.
Todd EvansDepartment of Surgery, Weill Cornell Medicine, New York, NY 10065, USA tre2003@med.cornell.edu.ORCID 0000-0002-7148-9849
Cornell University · US

Funding

A Gata456 Pipeline of DiscoveryR35HL135778 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI EVANS, TODD R · 2017 to 2023
$5.7M
Training Program in Developmental BiologyT32HD060600 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI BAO, ZHIRONG, STUHLMANN, HEIDI · 2010 to 2024
$3.5M
NHLBI NIH HHS R35 HL135778NICHD NIH HHS T32 HD060600
6 · The paper itself

Abstract

The Gata4/5/6 sub-family of zinc finger transcription factors regulate many aspects of cardiogenesis. However, critical roles in extra-embryonic endoderm also challenge comprehensive analysis during early mouse cardiogenesis, while zebrafish models have previously relied on knockdown assays. We generated targeted deletions to disrupt each

Indexed as

Gene Expression Regulation, DevelopmentalAllelesAnimalsGATA4 Transcription FactorGATA5 Transcription FactorGATA6 Transcription FactorGene DosageGene TargetingGenotypeHeartMorphogenesisMutationOrganogenesisPhenotypeZebrafishGATA4 Transcription FactorGATA5 Transcription FactorGATA6 Transcription FactorEmbryogenesisHeart developmentMorphogenesisProgenitor cellsTranscriptional regulation

Identifiers

PMID32580940
PMCPMC7327998
OpenAlexW3038002417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.