Evidence map›Paper›PMID 32580662›Full record

ReviewAnnual review of vision science2020

Anatomy and Function of the Primate Entorhinal Cortex.

Aaron D Garcia, Elizabeth A Buffalo

Open access · greenAbstract readReview
In one paragraph

Review in Annual review of vision science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 86 citations in OpenAlex.

  1. Loss of neuronal population organization links pathology to behavior in a model of Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Aaron D GarciaGraduate Program in Neuroscience, University of Washington, Seattle, Washington 98195, USA.
Elizabeth A BuffaloDepartment of Physiology and Biophysics, School of Medicine, University of Washington, Seattle, Washington 98195, USA; email: ebuffalo@uw.edu.
University of Washington · US

Funding

Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
YNPRC NHP CLINICAL MEDICINE RESIDENCY PROGRAM - SUPPLEMENTP51RR000165 · NCRR · EMORY UNIVERSITY · PI ALTMAN, JOHN DAVID · 1985 to 2011
$114.0M
Neural circuit theory and trained recurrent network modeling of rapid learningU19NS107609 · NINDS · UNIVERSITY OF WASHINGTON · PI FREEDMAN, DAVID J · 2018 to 2022
$12.6M
Neuronal Synchronization in the Medial Temporal Lobe and Memory FormationR01MH080007 · NIMH · UNIVERSITY OF WASHINGTON · PI BUFFALO, ELIZABETH A · 2008 to 2018
$4.7M
Temporally coordinated activity in the primate hippocampus supporting memory formationR01MH117777 · NIMH · UNIVERSITY OF WASHINGTON · PI BUFFALO, ELIZABETH A · 2018 to 2022
$3.3M
The Neural Basis of Relational MemoryR01MH093807 · NIMH · UNIVERSITY OF WASHINGTON · PI BUFFALO, ELIZABETH A · 2012 to 2016
$2.6M
NCRR NIH HHS P51 RR000165NIH HHS P51 OD010425NIMH NIH HHS R01 MH080007NIMH NIH HHS R01 MH093807NIMH NIH HHS R01 MH117777NINDS NIH HHS U19 NS107609
6 · The paper itself

Abstract

The entorhinal cortex (EC) is a critical element of the hippocampal formation located within the medial temporal lobe (MTL) in primates. The EC has historically received attention for being the primary mediator of cortical information going into and coming from the hippocampus proper. In this review, we highlight the significance of the EC as a major player in memory processing, along with other associated structures in the primate MTL. The complex, convergent topographies of cortical and subcortical input to the EC, combined with short-range intrinsic connectivity and the selective targeting of EC efferents to the hippocampus, provide evidence for subregional specialization and integration of information beyond what would be expected if this structure were a simple conduit of information for the hippocampus. Lesion studies of the EC provide evidence implicating this region as critical for memory and the flexible use of complex relational associations between experienced events. The physiology of this structure's constituent principal cells mirrors the complexity of its anatomy. EC neurons respond preferentially to aspects of memory-dependent paradigms including object, place, and time. EC neurons also show striking spatial representations as primates explore visual space, similar to those identified in rodents navigating physical space. In this review, we highlight the great strides that have been made toward furthering our understanding of the primate EC, and we identify paths forward for future experiments to provide additional insight into the role of this structure in learning and memory.

Indexed as

AnimalsEntorhinal CortexHippocampusMemoryNeuronsPrimatesentorhinal cortexepisodic memorygrid cellshippocampusperirhinal cortexvisual exploration

Identifiers

PMID32580662
PMCPMC12889097
OpenAlexW3037023113

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.