Evidence map›Paper›PMID 32580632›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2020

Epidemiology and Risk of Amputation in Patients With Diabetes Mellitus and Peripheral Artery Disease.

J Aaron Barnes, Mark A Eid, Mark A Creager, Philip P Goodney

2 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 227 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
227citing papers in PubMed, 11 pooled it
39.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05063474 terminatednot on this mapstarted 2021, after this paper: background citation

Microvascular Reactivity in People With Peripheral Artery Disease: a Pilot Study to Determine Reliability, Validity, and Sensitivity to Change

TypeobservationalSponsorColumbia UniversityRan2021 to 2023Enrolled3ConditionsPeripheral Artery DiseaseArmsNo Intervention-Clinical Assessments only
NCT07621770 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Nutritional Status in Adults With Diabetic Foot in an Outpatient Wound Clinic: A Feasibility and Pilot Study

TypeobservationalSponsorHvidovre University HospitalRan2026 to 2026Enrolled30ConditionsDiabetic Foot Ulcers (DFU), Nutrition Assessment, Malnutrition (Calorie), Ulcer FootArmsProtein supplementation and nutrition education
3 · Its place in the literature

Who cites it

227 citing papers in PubMed, 11 syntheses or guidelines pooled it, 469 citations in OpenAlex.

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  5. Omega-3 fatty acids for intermittent claudication.The Cochrane database of systematic reviews · 2024
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  16. Lower extremity amputations in Switzerland: Trends in patients with and without diabetes, 2013-2023.International journal of cardiology. Cardiovascular risk and prevention · 2026
    Article
  17. Prehabilitation for Limb Salvage Surgery: A Practical and Evidence-based Guide.Plastic and reconstructive surgery. Global open · 2026
    Article
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  20. Review

167 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

J Aaron BarnesFrom the Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH.
Mark A EidFrom the Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH.
Mark A CreagerFrom the Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH.
Philip P GoodneyFrom the Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH.
Dartmouth–Hitchcock Medical Center · US

Funding

American Heart Association-American Stroke Association 18SFRN33900147
6 · The paper itself

Abstract

Peripheral artery disease (PAD) stems from atherosclerosis of lower extremity arteries with resultant arterial narrowing or occlusion. The most severe form of PAD is termed chronic limb-threatening ischemia and carries a significant risk of limb loss and cardiovascular mortality. Diabetes mellitus is known to increase the incidence of PAD, accelerate disease progression, and increase disease severity. Patients with concomitant diabetes mellitus and PAD are at high risk for major complications, such as amputation. Despite a decrease in the overall number of amputations performed annually in the United States, amputation rates among those with both diabetes mellitus and PAD have remained stable or even increased in high-risk subgroups. Within this cohort, there is significant regional, racial/ethnic, and socioeconomic variation in amputation risk. Specifically, residents of rural areas, African-American and Native American patients, and those of low socioeconomic status carry the highest risk of amputation. The burden of amputation is severe, with 5-year mortality rates exceeding those of many malignancies. Furthermore, caring for patients with PAD and diabetes mellitus imposes a significant cost to the healthcare system-estimated to range from $84 billion to $380 billion annually. Efforts to improve the quality of care for those with PAD and diabetes mellitus must focus on the subgroups at high risk for amputation and the disparities they face in the receipt of both preventive and interventional cardiovascular care. Better understanding of these social, economic, and structural barriers will prove to be crucial for cardiovascular physicians striving to better care for patients facing this challenging combination of chronic diseases.

Indexed as

Amputation, SurgicalDiabetes ComplicationsHealth Care CostsHumansPeripheral Arterial DiseaseRiskRisk Factorsamputationatherosclerosisdiabetes mellituslower extremityperipheral artery disease

Identifiers

PMID32580632
PMCPMC7377955
OpenAlexW3037958843

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.