Evidence map›Paper›PMID 32580506›Full record

ArticleMolecules (Basel, Switzerland)2020

Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking.

Suaad A Audat, Nizar A Al-Shar'i, Buthina A Al-Oudat, Amanda Bryant-Friedrich, Mel F Bedi, Aref L Zayed, Qosay A Al-Balas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Exploring the Antibacterial Potential ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Suaad A AudatDepartment of Chemistry, College of Science and Arts, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan.ORCID 0000-0003-4486-4962
Nizar A Al-Shar'iDepartment of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan.
Buthina A Al-OudatDepartment of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan.
Amanda Bryant-FriedrichDepartment of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH 43606, USA.
Mel F BediDepartment of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH 43606, USA.ORCID 0000-0002-4976-5157
Aref L ZayedDepartment of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan.ORCID 0000-0003-0211-1866
Qosay A Al-BalasDepartment of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan.ORCID 0000-0002-8350-900X
Jordan University of Science and Technology · JOUniversity of Toledo · US

Funding

Deanship of Scientific Research at Jordan University of Science and Technology 20150357University of Toledo Foundation Cancer Research Fund 2400624
6 · The paper itself

Abstract

Leukotriene B4 (LTB4) is a potent, proinflammatory lipid mediator implicated in the pathologies of an array of inflammatory diseases and cancer. The biosynthesis of LTB4 is regulated by the leukotriene A4 hydrolase (LTA

Indexed as

Catalytic DomainDrug DesignEnzyme InhibitorsEpoxide HydrolasesHumansInflammationMolecular Docking SimulationNeoplasmsStructure-Activity RelationshipEnzyme InhibitorsEpoxide Hydrolasesleukotriene A4 hydrolaseanti-cancer and anti-inflammatory agentsleukotriene A4 hydrolaseleukotriene B4moelcular dockingpharmacophore modeling

Identifiers

PMID32580506
PMCPMC7356593
OpenAlexW3036305768

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.