ReviewJournal of clinical medicine2020
The Cerebral Localization of Pain: Anatomical and Functional Considerations for Targeted Electrical Therapies.
Review in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- [Anger-related interventions for treatment of chronic pain : A systematic review].Schmerz (Berlin, Germany) · 2026Pooled it
- Pediatric migraine: Neurodevelopmental mechanisms, clinical phenotypes, and modern therapeutics.World journal of clinical pediatrics · 2026Review
- Cardiac interoception in chronic pain: no association between interoceptive accuracy and symptom report.Frontiers in psychiatry · 2026Article
- Exploring the Thalamus as a Target for Neuropathic Pain Management: An Integrative Review.Cureus · 2024Review
- The Role of the Insula in Chronic Pain and Associated Structural Changes: An Integrative Review.Cureus · 2024Review
- Psychophysical pain encoding in the cingulate cortex predicts responsiveness of electrical stimulation.medRxiv : the preprint server for health sciences · 2023Article
- A novel thermoelectric device integrated with a psychophysical paradigm to study pain processing in human subjects.Journal of neuroscience methods · 2023Article
- Characterization of spatiotemporal dynamics of binary and graded tonic pain in humans using intracranial recordings.PloS one · 2023Article
- Deep Brain Stimulation, Stereotactic Radiosurgery and High-Intensity Focused Ultrasound Targeting the Limbic Pain Matrix: A Comprehensive Review.Pain and therapy · 2022Review
- Special Issue: Trends in Clinical Deep Brain Stimulation.Journal of clinical medicine · 2021Article
- The Future of Training and Practice in Neuromodulation: An Interventional Psychiatry Perspective.Frontiers in psychiatry · 2021Article
- Gray and white matter abnormalities in primary trigeminal neuralgia with and without neurovascular compression.The journal of headache and pain · 2020Article
- A Narrative Review of Neuroimaging Studies in Acupuncture for Migraine.Pain research & managementReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Millions of people in the United States are affected by chronic pain, and the financial cost of pain treatment is weighing on the healthcare system. In some cases, current pharmacological treatments may do more harm than good, as with the United States opioid crisis. Direct electrical stimulation of the brain is one potential non-pharmacological treatment with a long history of investigation. Yet brain stimulation has been far less successful than peripheral or spinal cord stimulation, perhaps because of our limited understanding of the neural circuits involved in pain perception. In this paper, we review the history of using electrical stimulation of the brain to treat pain, as well as contemporary studies identifying the structures involved in pain networks, such as the thalamus, insula, and anterior cingulate. We propose that the thermal grill illusion, an experimental pain model, can facilitate further investigation of these structures. Pairing this model with intracranial recording will provide insight toward disentangling the neural correlates from the described anatomic areas. Finally, the possibility of altering pain perception with brain stimulation in these regions could be highly informative for the development of novel brain stimulation therapies for chronic pain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.