ArticleJournal of clinical medicine2020
A Randomized Trial of Deep Brain Stimulation to the Subcallosal Cingulate and Nucleus Accumbens in Patients with Treatment-Refractory, Chronic, and Severe Anorexia Nervosa: Initial Results at 6 Months of Follow Up.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- The effects of neuromodulation interventions on the eating behaviors of patients with eating disorders compared to healthy controls, sham therapies, and other therapeutic approaches: A systematic review.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Treatment effectiveness for comorbid anorexia nervosa and obsessive-compulsive disorder: a systematic review.International journal of psychiatry in clinical practice · 2025Pooled it
- Efficacy and safety of deep brain stimulation for treatment-refractory anorexia nervosa: a systematic review and meta-analysis.Translational psychiatry · 2022Pooled it
- Functional psychosurgery in psychiatry: indications and preoperative evaluation. A narrative review.Frontiers in psychiatry · 2026Review
- Efficacy of pharmacological and non-pharmacological interventions for the treatment of anorexia nervosa in adolescents and adults (EfaNosa): protocol for a network meta-analysis.Systematic reviews · 2025Article
- Deep Brain Stimulation in Treatment-Resistant Psychiatric Disorders: Efficacy, Safety, and Future Directions.Brain sciences · 2025Review
- Nucleus accumbens deep brain stimulation in adult patients suffering from severe and enduring anorexia nervosa (STIMARS): protocol for a pilot study.Frontiers in psychiatry · 2025Article
- Structural connectivity modifications following deep brain stimulation of the subcallosal cingulate and nucleus accumbens in severe anorexia nervosa.Acta neurochirurgica · 2024Article
- Severe enduring anorexia nervosa (SE-AN) treatment options and their effectiveness: a review of literature.Journal of eating disorders · 2024Review
- Neuromodulation of Eating Disorders: A Review of Underlying Neural Network Activity and Neuromodulatory Treatments.Brain sciences · 2024Review
- Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity.Molecular psychiatry · 2023Article
- Neural effects of deep brain stimulation on reward and loss anticipation and food viewing in anorexia nervosa: a pilot study.Journal of eating disorders · 2023Article
- Refractory anorexia nervosa in adulthood and nucleus accumbens deep brain stimulation.Surgical neurology international · 2023Article
- Innovative perspectives in limbic surgery using deep brain stimulation.Frontiers in neuroscience · 2023Review
- A Clinical Overview of Anorexia Nervosa and Overcoming Treatment Resistance.Avicenna journal of medicine · 2023Review
- A Longitudinal Magnetoencephalographic Study of the Effects of Deep Brain Stimulation on Neuronal Dynamics in Severe Anorexia Nervosa.Frontiers in behavioral neuroscience · 2022Article
- Neuromodulation and Eating Disorders.Current psychiatry reports · 2022Review
- Deep Brain Stimulation of the Nucleus Accumbens in Severe Enduring Anorexia Nervosa: A Pilot Study.Frontiers in behavioral neuroscience · 2022Article
- Deep brain stimulation for psychiatric disorders: role of imaging in identifying/confirming DBS targets, predicting, and optimizing outcome and unravelling mechanisms of action.Psychoradiology · 2021Article
- Effects of Transcranial Direct Current Stimulation Treatment for Anorexia Nervosa.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe main objective of this study was to assess the safety and efficacy of deep brain stimulation (DBS) in patients with severe anorexia nervosa (AN).
methodsEight participants received active DBS to the subcallosal cingulate (SCC) or nucleus accumbens (NAcc) depending on comorbidities (affective or anxiety disorders, respectively) and type of AN. The primary outcome measure was body mass index (BMI).
resultsOverall, we found no significant difference (
conclusionDBS may be effective for some patients with severe AN. Cutaneous complications were observed. Longer term data are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.