Evidence map›Paper›PMID 32580384›Full record

ArticleInternational journal of molecular sciences2020

Molecular Epidemiology of B3 and D8 Measles Viruses through Hemagglutinin Phylogenetic History.

Silvia Bianchi, Marta Canuti, Giulia Ciceri, Maria Gori, Daniela Colzani, Marco Dura, Beatrice Marina Pennati, Melissa Baggieri, Fabio Magurano, Elisabetta Tanzi and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Silvia BianchiDepartment of Biomedical Sciences for Health, University of Milan, via Carlo Pascal 36, 20133 Milan, Italy.ORCID 0000-0002-1365-9408
Marta CanutiDepartment of Biology, Memorial University of Newfoundland, 232 Elizabeth Ave., St. John's, NL A1B 3X9, Canada.ORCID 0000-0002-9959-128X
Giulia CiceriDepartment of Biomedical Sciences for Health, University of Milan, via Carlo Pascal 36, 20133 Milan, Italy.ORCID 0000-0003-1331-5856
Maria GoriDepartment of Biomedical Sciences for Health, University of Milan, via Carlo Pascal 36, 20133 Milan, Italy.ORCID 0000-0001-6478-2791
Daniela ColzaniDepartment of Biomedical Sciences for Health, University of Milan, via Carlo Pascal 36, 20133 Milan, Italy.
Marco DuraDepartment of Biomedical Sciences for Health, University of Milan, via Carlo Pascal 36, 20133 Milan, Italy.
Beatrice Marina PennatiDepartment of Biomedical Sciences for Health, University of Milan, via Carlo Pascal 36, 20133 Milan, Italy.
Melissa BaggieriDepartment of Infectious Diseases, National Reference Laboratory for Measles and Rubella, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy.
Fabio MaguranoDepartment of Infectious Diseases, National Reference Laboratory for Measles and Rubella, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy.
Elisabetta TanziDepartment of Biomedical Sciences for Health, University of Milan, via Carlo Pascal 36, 20133 Milan, Italy.ORCID 0000-0002-4119-701X
Antonella AmendolaDepartment of Biomedical Sciences for Health, University of Milan, via Carlo Pascal 36, 20133 Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Of the 24 known measles genotypes, only D8 and B3 are responsible for outbreaks in the last years in Europe, Asia, and America. In this study the H gene of 92 strains circulating between 2015 and 2019 in Lombardy, Northern Italy, and 1273 H sequences available in GenBank were analyzed in order to evaluate the genetic variability and to assess the conservation of the immunodominant sites. Overall, in Lombardy we observed the presence of four different B3 and three different D8 clusters, each one of them including sequences derived from viruses found in both vaccinated and unvaccinated subjects. Worldwide, the residue 400 within the H protein, a position located within the main immune epitope, is mutated in all circulating strains that belong to the two globally endemic genotypes, B3 and D8. Our data demonstrate the usefulness of measles virus (MV) H gene sequencing. Indeed, the monitoring the H protein epitopes of circulating strains could be included in the measles laboratory surveillance activities in order to improve and optimize strategies for measles control, as countries go towards elimination phase.

Indexed as

Genetic VariationMolecular EpidemiologyPhylogenyAmino Acid SequenceGenotypeHemagglutininsHumansItalyMeaslesMeasles virusSequence Analysis, DNASequence HomologyViral ProteinsViral VaccinesHemagglutininsViral ProteinsViral Vaccinesgenotype B3genotype D8hemagglutininH geneimmunodominant epitopesmeasles surveillance strategiesmeasles virus

Identifiers

PMID32580384
PMCPMC7352894

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.