Evidence map›Paper›PMID 32580326›Full record

ReviewMolecules (Basel, Switzerland)2020

Role of Lipid-Based and Polymer-Based Non-Viral Vectors in Nucleic Acid Delivery for Next-Generation Gene Therapy.

Aniket Wahane, Akaash Waghmode, Alexander Kapphahn, Karishma Dhuri, Anisha Gupta, Raman Bahal

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 185 citations in OpenAlex.

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  20. mRNA vaccines as cancer therapies.Chinese medical journal · 2024
    Review

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Aniket WahaneDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA.
Akaash WaghmodeDepartment of Chemistry, Wesleyan University, Middletown, CT 06459, USA.
Alexander KapphahnDepartment of Chemistry, Wesleyan University, Middletown, CT 06459, USA.
Karishma DhuriDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA.
Anisha GuptaDepartment of Chemistry, Wesleyan University, Middletown, CT 06459, USA.
Raman BahalDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA.
University of Connecticut · USWesleyan University · US

Funding

Developing next generation synthetic nucleic acid analogous for sickle cell disease gene editingR01HL147028 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI BAHAL, RAMAN · 2020 to 2024
$2.0M
NHLBI NIH HHS R01 HL147028NIH HHS 1R01HL147028-01A1
6 · The paper itself

Abstract

The field of gene therapy has experienced an insurgence of attention for its widespread ability to regulate gene expression by targeting genomic DNA, messenger RNA, microRNA, and short-interfering RNA for treating malignant and non-malignant disorders. Numerous nucleic acid analogs have been developed to target coding or non-coding sequences of the human genome for gene regulation. However, broader clinical applications of nucleic acid analogs have been limited due to their poor cell or organ-specific delivery. To resolve these issues, non-viral vectors based on nanoparticles, liposomes, and polyplexes have been developed to date. This review is centered on non-viral vectors mainly comprising of cationic lipids and polymers for nucleic acid-based delivery for numerous gene therapy-based applications.

Indexed as

Gene Transfer TechniquesDNAGenetic TherapyGenetic VectorsHumansLipidsNanoparticlesPolymersRNA, Small InterferingDNALipidsPolymersRNA, Small InterferingDNAgene therapylipid nanoparticlesmRNAnanoparticlesnucleic acids

Identifiers

PMID32580326
PMCPMC7356024
OpenAlexW3035863220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.