ArticleDiabetic medicine : a journal of the British Diabetic Association2020
Biopsychosocial factors associated with a current depressive episode in diabetes: the ELSA-Brasil study.
Article in Diabetic medicine : a journal of the British Diabetic Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Biopsychosocial and Nutritional Factors of Depression among Type 2 Diabetes Mellitus Patients: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Beyond association: Examining overweight as a mediator in the link between depression and diabetes.World journal of diabetes · 2025Article
- Mesenchymal Stem Cells Restore Endothelial Integrity and Alleviate Emotional Impairments in a Diabetic Mouse Model via Inhibition of MMP-9 Activity.International journal of molecular sciences · 2025Article
- Effect modification of tumor necrosis factor-α on the kynurenine and serotonin pathways in major depressive disorder on type 2 diabetes mellitus.European archives of psychiatry and clinical neuroscience · 2024Article
- Understanding the Relationship between Environmental Factors and Mental Health Status among Type 2 Diabetes Mellitus Patients: A Scoping Review.Iranian journal of public health · 2024Article
- Optimal cardiovascular health is associated with slower cognitive decline.European journal of neurology · 2024Article
- Biopsychosocial factors associated with a current depressive episode in diabetes: the ELSA-Brasil study.Diabetic medicine : a journal of the British Diabetic Association · 2020Article
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Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
Abstract
aimsDepression is more prevalent in people with diabetes, and is associated with worse diabetes outcomes. Depression in diabetes is more treatment resistant, and as underlying mechanisms are unknown, development of more effective treatment strategies is complicated. A biopsychosocial model may improve our understanding of the pathophysiology, and therewith help improving treatment options.
methodsDiabetes was diagnosed according to American Diabetes Association (ADA) criteria and a current depressive episode according to the International Classification of Diseases (ICD-10), based on the Clinical Interview Schedule Revised (CIS-R). From the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), we included 455 participants without diabetes with a current depressive episode and 10 900 without either diabetes or a current depressive episode. Furthermore, 2183 participants had diabetes alone and 106 had both diabetes and a current depressive episode. Variable selection was based on their relationship with depression and/or diabetes. Multinomial multivariate logistic regression was used to determine how the models differed between participants with and without diabetes.
resultsA current depressive episode in diabetes was related to being older and female, having poorer education, financial problems, experiencing discrimination at work, home and school, higher waist circumference, albumin to creatinine ratio and insulin resistance, and the presence of hypertension and cardiovascular disease. In non-diabetes, a current depressive disorder was related to being female, not being black, low income, psychological and social factors, non-current alcohol use, lower HDL cholesterol, higher insulin resistance and the presence of cardiovascular disease.
conclusionsA current depressive episode in the presence compared with the absence of diabetes was related more to biological than to psychosocial factors.
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