Evidence map›Paper›PMID 32580035›Full record

SynthesisCritical reviews in oncology/hematology2020

The effect of exercise and motor interventions on physical activity and motor outcomes during and after medical intervention for children and adolescents with acute lymphoblastic leukemia: A systematic review.

Alison Coombs, Hannah Schilperoort, Barbara Sargent

3 registry-linked trialsOpen access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Critical reviews in oncology/hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 34 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 4 pooled it
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05059847 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Impact of Cross-training on Induction Treatment Response in Acute Lymphoblastic Leukemia Adults

TypeinterventionalSponsorHospital General de MexicoRan2021 to 2023Enrolled114ConditionsAcute Lymphoblastic Leukemia, Adult B-CellArmsTraining
NCT06846294 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

OBesity PREVention in Children and Young People Treated with ALLtogetheR: Prehabilitation Feasibility Intervention

TypeinterventionalSponsorUniversity of ExeterRan2025 to 2029Enrolled90ConditionsDiet Intervention, Physical Activity Intervention, Standard Care ControlArmsDiet, Diet and physical activity
NCT07522905 narecruitingnot on this mapstarted 2026, after this paper: background citation

The Impact of a 12-week Virtual Buddy-movement Therapy on the Psychomotor and Social Development of Pediatric Oncology Patients in Remission

TypeinterventionalSponsorComenius UniversityRan2026 to 2027Enrolled24ConditionsPrecursor Cell Lymphoblastic Leukemia-LymphomaArmsVirtual BUDDY-Movement Therapy
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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  16. Walking inability in children during early treatment of acute lymphoblastic leukaemia: incidence and risk factors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alison CoombsChildren's Hospital Los Angeles, Division of Pediatric Rehabilitation Medicine, 4650 Sunset Blvd., Los Angeles, CA, 90027, United States; University of Southern California, Division of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry, Los Angeles, CA, United States. Electronic address: acoombs@chla.usc.edu.
Hannah SchilperoortUniversity of Southern California, Norris Medical Library, Los Angeles, CA, United States.
Barbara SargentUniversity of Southern California, Division of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry, Los Angeles, CA, United States.
University of Southern California · US

Funding

Rehabilitation Research Career Development ProgramK12HD055929 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BROWN, DAVID A · 2007 to 2021
$11.7M
NICHD NIH HHS K12 HD055929
6 · The paper itself

Abstract

backgroundChildren with acute lymphoblastic leukemia (ALL) experience detrimental effects on motor function during and after chemotherapy. The objective of this systematic review was to evaluate the effect of exercise and motor interventions on physical activity and motor outcomes of children with ALL during and after chemotherapy.

methodsTen databases were searched. Nineteen studies were included: 11 randomized clinical trials (RCT), 2 controlled clinical trials (CCT), and 6 cohort studies.

resultsParticipants included 508 children with ALL. Between-group results from RCTs and CCTs supported that exercise and motor intervention improved: fatigue during acute chemotherapy; physical activity, range of motion (ROM), strength, bone mineral density, aerobic capacity, and fatigue during maintenance chemotherapy; functional mobility, ROM, strength, and aerobic capacity during post-treatment survivorship; and participation, physical activity, ROM, strength, and coordination during multiple-phase interventions.

conclusionLow quality evidence supports the efficacy of motor and exercise interventions for children and adolescents with ALL.

Indexed as

ExercisePrecursor Cell Lymphoblastic Leukemia-LymphomaAdolescentBone DensityChildExercise ToleranceFatigueHumansALLExerciseLate effectsLeukemiaMotor interventionsPediatric oncologyPhysical activity

Identifiers

PMID32580035
PMCPMC8359930
OpenAlexW3032063223

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.