Evidence map›Paper›PMID 32579998›Full record

ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2020

Patterns of practice for adaptive and real-time radiation therapy (POP-ART RT) part II: Offline and online plan adaption for interfractional changes.

Jenny Bertholet, Gail Anastasi, David Noble, Arjan Bel, Ruud van Leeuwen, Toon Roggen, Michael Duchateau, Sara Pilskog, Cristina Garibaldi, Nina Tilly and 5 more

Registry-linked trialAbstract read
In one paragraph

Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07259447 (Efficiency of Contemporary Off-line Adaptive Radiotherapy for Lung Cancer), which is not on this map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07259447 narecruitingnot on this mapstarted 2024, after this paper: background citation

Efficiency of Contemporary Off-line Adaptive Radiotherapy for Lung Cancer

TypeinterventionalSponsorUniversitaire Ziekenhuizen KU LeuvenRan2024 to 2026Enrolled30ConditionsNSCLC (Advanced Non-small Cell Lung Cancer), Adaptive RadiotherapyArmsCBCT-based adaptive radiotherapy
3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

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  4. Review
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  13. Real-Time Dose-Guided Radiation Therapy.International journal of radiation oncology, biology, physics · 2025
    Review
  14. Article
  15. Article
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  17. Article
  18. Review
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  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jenny BertholetJoint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, United Kingdom; Division of Medical Radiation Physics, Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Switzerland. Electronic address: jenny.bertholet@insel.ch.
Gail AnastasiDepartment of Medical Physics, Royal Surrey County Hospital, St. Luke's Cancer Centre, Guildford, United Kingdom.
David NobleCancer Research UK VoxTox Research Group, University of Cambridge Department of Oncology, Cambridge Biomedical Campus, Addenbrooke's Hospital, United Kingdom.
Arjan BelAmsterdam UMC, Department of Radiation Oncology, The Netherlands.
Ruud van LeeuwenDepartment of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.
Toon RoggenApplied Research, Varian Medical Systems Imaging Laboratory GmbH, Dättwil, Switzerland.
Michael DuchateauMIM Software Inc., Cleveland, United States.
Sara PilskogDepartment of Oncology and Medical Physics, Haukeland University Hospital, Bergen, Norway; Department of Physics and Technology, University of Bergen, Norway.
Cristina GaribaldiIEO, European Institute of Oncology IRCCS, Unit of Radiation Research, Milan, Italy.
Nina TillyElekta Instruments AB, Stockholm, Sweden; Medical Radiation Physics, Department of Immunology, Genetics and Pathology, Uppsala University, Sweden.
Rafael García-MolláServicio de Radiofísica y Protección Radiológica, Consorcio Hospital General Universitario de Valencia, Spain.
Jorge BonaqueServicio de Radiofísica y Protección Radiológica, Consorcio Hospitalario Provincial de Castellón, Castelló de la Plana, Spain.
Uwe OelfkeJoint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, United Kingdom.
Marianne C AznarDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, The Christie NHS Foundation Trust, United Kingdom; Nuffield Department of Population Health, University of Oxford, United Kingdom.
Ben HeijmenErasmus MC Cancer Institute, Department of Radiation Oncology, Rotterdam, The Netherlands.

Funding

Cancer Research UK 21133Cancer Research UK 28284Cancer Research UK C33589/A19727Cancer Research UK C33589/A19908Department of Health DRF-2018-11-ST2-067Medical Research Council MC_U137686858
6 · The paper itself

Abstract

purposeThe POP-ART RT study aims to determine to what extent and how intrafractional real-time respiratory motion management (RRMM), and plan adaptation for interfractional anatomical changes (ART) are used in clinical practice and to understand barriers to implementation. Here we report on part II: ART using more than one plan per target per treatment course. MATERIALS AND

methodsA questionnaire on the current practice of ART, wishes for expansion or implementation, and barriers to implementation was distributed worldwide. Four types of ART were discriminated: daily online replanning, online plan library, protocolled offline replanning (all three based on a protocol), and ad-hoc offline replanning.

resultsThe questionnaire was completed by 177 centres from 40 countries. ART was used by 61% of respondents (31% with protocol) for a median (range) of 3 (1-8) tumour sites. CBCT/MVCT was the main imaging modality except for online daily replanning (11 users) where 10 users used MR. Two thirds of respondents wished to implement ART for a new tumour site; 40% of these had plans to do it in the next 2 years. Human/material resources and technical limitations were the main barriers to further use and implementation.

conclusionsART was used for a broad range of tumour sites, mainly with ad-hoc offline replanning and for a median of 3 tumour sites. There was a large interest in implementing ART for more tumour sites, mainly limited by human/material resources and technical limitations. Daily online replanning was primarily performed on MR-linacs.

Indexed as

Radiotherapy Planning, Computer-AssistedHumansMotionRadiotherapy DosageAdaptive radiotherapyImage-guided radiotherapy (IGRT)Interfractional motionMR-guided radiotherapyPlan libraryPlan of the day

Identifiers

PMID32579998
PMCPMC7758781

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.