Evidence map›Paper›PMID 32579912›Full record

ArticleCell reports2020

Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury.

Kevin A Guttenplan, Benjamin K Stafford, Rana N El-Danaf, Drew I Adler, Alexandra E Münch, Maya K Weigel, Andrew D Huberman, Shane A Liddelow

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 155 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed, 3 pooled it
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

155 citing papers in PubMed, 3 syntheses or guidelines pooled it, 214 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Primary Cilia of Astrocytes in the Retina in Development and Disease.Investigative ophthalmology & visual science · 2026
    Article
  5. Review
  6. Neuroinflammation in glaucoma: a myriad of cellular pathways and players.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. IL1A enhances TNF-induced retinal ganglion cell death.Frontiers in aging neuroscience · 2026
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Kevin A GuttenplanDepartment of Neurobiology, Stanford University, Stanford, CA 94305, USA. Electronic address: kguttenp@stanford.edu.
Benjamin K StaffordSalk Institute for Biological Studies, La Jolla, CA 92037, USA.
Rana N El-DanafDepartment of Neurobiology, Stanford University, Stanford, CA 94305, USA; Center for Genomics and Systems Biology, NYU Abu Dhabi, Abu Dhabi, United Arab Emirates.
Drew I AdlerNeuroscience Institute, NYU School of Medicine, New York, NY 10016, USA.
Alexandra E MünchDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Maya K WeigelDepartment of Neurobiology, Stanford University, Stanford, CA 94305, USA.
Andrew D HubermanDepartment of Neurobiology, Stanford University, Stanford, CA 94305, USA; Department of Ophthalmology, Stanford University, Stanford, CA 94305, USA.
Shane A LiddelowNeuroscience Institute, NYU School of Medicine, New York, NY 10016, USA; Department of Neuroscience and Physiology, NYU School of Medicine, New York, NY 10016, USA; Department of Ophthalmology, NYU School of Medicine, New York, NY 10016, USA. Electronic address: shane.liddelow@nyulangone.org.
Stanford University · USNeurosciences Institute · USNew York University Abu Dhabi · AESalk Institute for Biological Studies · US

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
Molecular and functional regeneration of the accessory optic pathwayR01EY027713 · NEI · JOHNS HOPKINS UNIVERSITY · PI HUBERMAN, ANDREW D, KOLODKIN, ALEX L · 2017 to 2020
$2.4M
Promoting optic nerve and retinofugal pathway regenerationR01EY026100 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HUBERMAN, ANDREW D · 2016 to 2019
$1.6M
NEI NIH HHS P30 EY026877NEI NIH HHS R01 EY026100NEI NIH HHS R01 EY027713
6 · The paper itself

Abstract

Glaucoma is a neurodegenerative disease that features the death of retinal ganglion cells (RGCs) in the retina, often as a result of prolonged increases in intraocular pressure. We show that preventing the formation of neuroinflammatory reactive astrocytes prevents the death of RGCs normally seen in a mouse model of glaucoma. Furthermore, we show that these spared RGCs are electrophysiologically functional and thus still have potential value for the function and regeneration of the retina. Finally, we demonstrate that the death of RGCs depends on a combination of both an injury to the neurons and the presence of reactive astrocytes, suggesting a model that may explain why reactive astrocytes are toxic only in some circumstances. Altogether, these findings highlight reactive astrocytes as drivers of RGC death in a chronic neurodegenerative disease of the eye.

Indexed as

AnimalsAstrocytesAxonsCell DeathCell ShapeComplement C1qDendritesDisease Models, AnimalGlaucomaGliosisInterleukin-1Intraocular PressureMice, KnockoutMicrospheresNeuronsNeurotoxinsC1qa protein, mouseComplement C1qInterleukin-1NeurotoxinsTumor Necrosis Factor-alphaastrocytesastrogliosisglaucomaglianeurodegenerationneuroprotectionoptic nerve crushreactive astrocyte

Identifiers

PMID32579912
PMCPMC8091906
OpenAlexW3037075657

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.