Evidence map›Paper›PMID 32579891›Full record

ReviewAdvanced drug delivery reviews2020

Near-infrared fluorescence imaging in immunotherapy.

Yuanyuan Ji, Catherine Jones, Yoonji Baek, G Kate Park, Satoshi Kashiwagi, Hak Soo Choi

Open access · greenAbstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 150 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Journal of pharmaceutical analysis · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Indocyanine Green-Labeled Platelets for Survival and Recovery Studies.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2024
    Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Yuanyuan JiScientific Research Centre, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Catherine JonesGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Yoonji BaekGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
G Kate ParkGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Satoshi KashiwagiGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: skashiwagi@mgh.harvard.edu.
Hak Soo ChoiGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: hchoi12@mgh.harvard.edu.
Massachusetts General Hospital · USHarvard University · USGordon Center for Medical Imaging · US

Funding

Near-infrared laser to replace chemical vaccine adjuvantR01AI105131 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI KASHIWAGI, SATOSHI · 2013 to 2016
$1.7M
Laser-based non-invasive immunotherapy for food allergyR21AI144103 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI KASHIWAGI, SATOSHI · 2019 to 2020
$433k
NIAID NIH HHS R01 AI105131NIAID NIH HHS R21 AI144103
6 · The paper itself

Abstract

Near-infrared (NIR) light possesses many suitable optophysical properties for medical imaging including low autofluorescence, deep tissue penetration, and minimal light scattering, which together allow for high-resolution imaging of biological tissue. NIR imaging has proven to be a noninvasive and effective real-time imaging methodology that provides a high signal-to-background ratio compared to other potential optical imaging modalities. In response to this, the use of NIR imaging has been extensively explored in the field of immunotherapy. To date, NIR fluorescence imaging has successfully offered reliable monitoring of the localization, dynamics, and function of immune responses, which are vital in assessing not only the efficacy but also the safety of treatments to design immunotherapies optimally. This review aims to provide an overview of the current research on NIR imaging of the immune response. We expect that the use of NIR imaging will expand further in response to the recent success in cancer immunotherapy. We will also offer our insights on how this technology will meet rapidly growing expectations in the future.

Indexed as

Infrared RaysAnimalsAntibodiesAntineoplastic Agents, ImmunologicalDrug Evaluation, PreclinicalHumansImmunotherapyNeoplasmsOptical ImagingPeptidesPhotosensitizing AgentsAntibodiesAntineoplastic Agents, ImmunologicalPeptidesPhotosensitizing AgentsImmune responsesImmunoimagingImmunotherapyNear-infrared fluorophores

Identifiers

PMID32579891
PMCPMC8450770
OpenAlexW3036829751

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.