ArticleCell stem cell2020
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids.
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Article in Cell stem cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 435 papers, 4 of them syntheses that pooled it.
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435citing papers in PubMed, 4 pooled it
–field-weighted citation impact
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
435 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Diabetes Mellitus, a Leading Comorbidity in COVID-19: an Insight on Pathophysiology, Molecular Interactions, and Comprehensive Management.Current microbiology · 2025Pooled it
- Pooled it
- When stem cells meet COVID-19: recent advances, challenges and future perspectives.Stem cell research & therapy · 2022Pooled it
- Liver organoids: From fabrication to application in liver diseases.Frontiers in physiology · 2022Pooled it
- SARS-CoV-2 and diabetes: a post-pandemic reappraisal.Diabetologia · 2026Review
- Hyperglycemia in Cats Infected by SARS-CoV-2: Pancreatic Alterations and Potential Antiviral Therapeutics.Microorganisms · 2026Review
- Liver Organoids: From Disease Modelling to Regenerative Medicine.Cell proliferation · 2026Review
- Trends and disparities in glycemic control and severe hyperglycemia in U.S. adults with diabetes mellitus before and during COVID-19 pandemic.Nutrition & metabolism · 2026Article
- Review
- Inhibition of host N-myristoylation compromises the infectivity of SARS-CoV-2 due to Golgi-bypassing egress.Nature communications · 2026Article
- Reimagining human-centric drug development with new approach methodologies.Science (New York, N.Y.) · 2026Review
- Pluripotency Factors Modulate Interferon Signaling in Embryonic Stem Cells.bioRxiv : the preprint server for biology · 2026Article
- [Advances in the construction and application of a novel liver organoid model for hepatitis B virus infection].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026Review
- SARS-CoV-2-infected cardiomyocytes exhibit upregulated necroptosis, but no evidence of mitochondrial permeability transition.Journal of molecular and cellular cardiology plus · 2026Article
- Identifying GFAP-expressing cell susceptibility to SARS-CoV-2 infection using human iPSC-derived neural cells.Scientific reports · 2026Article
- Organoids Gone Viral: A Comprehensive Review on Human Organoid Models to Study Viral Pathogenesis.Viruses · 2026Review
- Applications and limitations of pluripotent stem cell-derived liver organoids.Chinese medical journal · 2026Review
- Review
- The mechanisms underlying COVID-19 induced insulin resistance: a narrative review.Frontiers in endocrinology · 2026Review
- Organoid for Air Pollution Toxicity Assessment: Advances and Environmental Applicability.Environment & health (Washington, D.C.) · 2025Review
375 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
37 authors.
Liuliu YangDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA.
Yuling HanDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA.
Benjamin E Nilsson-PayantDepartment of Microbiology, Icahn School of Medicine at Mount Sinai. 1468 Madison Ave. New York, NY 10029, USA.
Vikas GuptaDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA.
Pengfei WangAaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Xiaohua DuanDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA; School of Life Science and Technology, ShanghaiTech University, 201210 Shanghai, China.
Xuming TangDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA.
Jiajun ZhuDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA.
Zeping ZhaoDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA.
Fabrice JaffréDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA.
Tuo ZhangGenomic Resource Core Facility, Weill Cornell Medicine, New York, NY 10065, USA.
Tae Wan KimThe Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA; Developmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA.
Oliver HarschnitzThe Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA; Developmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA.
David RedmondDivision of Regenerative Medicine, Ansary Stem Cell Institute, Weill Cornell Medicine, New York, NY 10065, USA.
Sean HoughtonDivision of Regenerative Medicine, Ansary Stem Cell Institute, Weill Cornell Medicine, New York, NY 10065, USA.
Chengyang LiuDepartment of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Ali NajiDepartment of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Gabriele CiceriThe Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA; Developmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA.
Sudha GuttikondaThe Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA; Developmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA; Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA.
Yaron BramDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA.
Duc-Huy T NguyenDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA.
Michele CioffiChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Vasuretha ChandarDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA.
Daisy A HoaglandDepartment of Microbiology, Icahn School of Medicine at Mount Sinai. 1468 Madison Ave. New York, NY 10029, USA.
Yaoxing HuangAaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Jenny XiangGenomic Resource Core Facility, Weill Cornell Medicine, New York, NY 10065, USA.
Hui WangSchool of Life Science and Technology, ShanghaiTech University, 201210 Shanghai, China; State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
David LydenChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Alain BorczukDepartment of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA.
Huanhuan Joyce ChenThe Pritzker School of Molecular Engineering, the Ben May Department for Cancer Research, the University of Chicago, IL, USA.
Lorenz StuderThe Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA; Developmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA.
Fong Cheng PanDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA. Electronic address: fcp2002@med.cornell.edu.
David D HoAaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA. Electronic address: dh2994@cumc.columbia.edu.
Benjamin R tenOeverDepartment of Microbiology, Icahn School of Medicine at Mount Sinai. 1468 Madison Ave. New York, NY 10029, USA. Electronic address: benjamin.tenoever@mssm.edu.
Todd EvansDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA. Electronic address: tre2003@med.cornell.edu.
Robert E SchwartzDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA. Electronic address: res2025@med.cornell.edu.
Shuibing ChenDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA. Electronic address: shc2034@med.cornell.edu.
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MPenn integrated Human Pancreas procurement and Analysis ProgramUC4DK112217 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BETTS, MICHAEL R, FELDMAN, MICHAEL D · 2016 to 2020
$17.8MTRAINING PROGRAM: MECHANISMS OF VIRUS-HOST INTERACTIONST32AI007647 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI Domenico Tortorella · 2000 to 2026
$11.5MGenetic Viral and Host Adaptations to Breach Species Barriers of HCVR01AI107301 · NIAID · PRINCETON UNIVERSITY · PI Thomas Pietschmann, Alexander Ploss · 2013 to 2026
$6.0MA Gata456 Pipeline of DiscoveryR35HL135778 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI EVANS, TODD R · 2017 to 2023
$5.7MOptimization of the engineered 3D hepatic microenvironment enhances pluripotent stem cell derived hepatocyteR01DK121072 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHWARTZ, ROBERT E · 2020 to 2024
$2.6MMetallothionein 1E as a Central Regulator of Human Pancreatic Beta Cell Function and SurvivalR01DK119667 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, SHUIBING · 2019 to 2022
$2.5MProgramming age in iPS models of Alzheimer's diseaseR01AG056298 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI STUDER, LORENZ P. · 2017 to 2021
$2.2MDiscovery of T1DM Associated Functional Variants in Human Pancreatic Beta Cell Development and SurvivalDP3DK111907 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, SHUIBING · 2016 to 2016
$2.0MModeling Hepatoblastoma using pluripotent stem cell derived hepatocyte-like cellsR01CA234614 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHWARTZ, ROBERT E · 2019 to 2023
$1.9MA High Content Chemical Screen to Identify the Drug Candidates Promoting Human Beta Cell ProliferationR01DK124463 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, SHUIBING · 2020 to 2023
$1.7MA High Throughput Screening to Identify Compounds Rescuing Human Pancreatic Beta Cell Function in Diabetic ConditionsR01DK116075 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, SHUIBING · 2018 to 2020
$1.3MNCI NIH HHS K99 CA226353NCI NIH HHS P30 CA008748NCI NIH HHS R00 CA226353NCI NIH HHS R01 CA234614NHLBI NIH HHS R35 HL135778NIAID NIH HHS R01 AI107301NIAID NIH HHS T32 AI007647NIA NIH HHS R01 AG056298NIDDK NIH HHS DP3 DK111907NIDDK NIH HHS R01 DK116075NIDDK NIH HHS R01 DK119667NIDDK NIH HHS R01 DK121072NIDDK NIH HHS R01 DK124463NIDDK NIH HHS R03 DK117252NIDDK NIH HHS UC4 DK112217NIMH NIH HHS F30 MH115616
Abstract
SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for physiological models to study SARS-CoV-2 infection using human disease-relevant cells. COVID-19 pathophysiology includes respiratory failure but involves other organ systems including gut, liver, heart, and pancreas. We present an experimental platform comprised of cell and organoid derivatives from human pluripotent stem cells (hPSCs). A Spike-enabled pseudo-entry virus infects pancreatic endocrine cells, liver organoids, cardiomyocytes, and dopaminergic neurons. Recent clinical studies show a strong association with COVID-19 and diabetes. We find that human pancreatic beta cells and liver organoids are highly permissive to SARS-CoV-2 infection, further validated using adult primary human islets and adult hepatocyte and cholangiocyte organoids. SARS-CoV-2 infection caused striking expression of chemokines, as also seen in primary human COVID-19 pulmonary autopsy samples. hPSC-derived cells/organoids provide valuable models for understanding the cellular responses of human tissues to SARS-CoV-2 infection and for disease modeling of COVID-19.
Indexed as
Models, BiologicalTropismAngiotensin-Converting Enzyme 2AnimalsAutopsyBetacoronavirusCell LineCoronavirus InfectionsCOVID-19HepatocytesHumansInduced Pluripotent Stem CellsLiverMiceOrganoidsPancreasACE2 protein, humanAce2 protein, mouseAngiotensin-Converting Enzyme 2Peptidyl-Dipeptidase Aalpha cellsbeta cellshuman pluripotent stem cellsliver organoidspancreatic endocrine cellsSARS-CoV-2
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