Evidence map›Paper›PMID 32579865›Full record

ArticleCell cycle (Georgetown, Tex.)2020

Five transcriptional factors reprogram fibroblast into myogenic lineage cells via paraxial mesoderm stage.

Meeyul Hwang, Eun-Joo Lee, Myung-Jin Chung, SunYoung Park, Kyu-Shik Jeong

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Meeyul HwangDepartment of Pathology, College of Veterinary Medicine, Kyungpook National University , Daegu, Republic of Korea.
Eun-Joo LeeDepartment of Pathology, College of Veterinary Medicine, Kyungpook National University , Daegu, Republic of Korea.
Myung-Jin ChungDepartment of Pathology, College of Veterinary Medicine, Kyungpook National University , Daegu, Republic of Korea.
SunYoung ParkDepartment of Pathology, College of Veterinary Medicine, Kyungpook National University , Daegu, Republic of Korea.
Kyu-Shik JeongDepartment of Pathology, College of Veterinary Medicine, Kyungpook National University , Daegu, Republic of Korea.ORCID 0000-0003-1725-638X
Kyungpook National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is hard to supply satellite cells as a cell source for therapy of muscle degenerative disease since the sampling of muscle tissue is very invasive to a patient with muscular disease. Direct conversion allows us to get specific cell types by transduction of defined transcriptional factors. To induce myogenic direct conversion, we transduced five transcriptional factors including Pax3, Sox2, Klf4, c-Myc, and Esrrb into mouse embryonic fibroblasts. We found that the transduction of the five transcriptional factors induced myogenic direct conversion of fibroblast. We revealed that the transduced cells with the five transcriptional factors were converted to myogenic lineage cells through a paraxial mesoderm-like stage. The expression level of myogenic-related genes of the transduced cells gradually increased as the passage increased. The induced myogenic lineage cells differentiated into muscle fibers

Indexed as

Cell LineageCellular ReprogrammingMuscle DevelopmentAnimalsBiomarkersCell DifferentiationEmbryo, MammalianFibroblastsGene Expression Regulation, DevelopmentalKruppel-Like Factor 4MesodermMiceMuscle CellsMuscle Fibers, SkeletalStem CellsTranscription FactorsBiomarkersKlf4 protein, mouseKruppel-Like Factor 4Transcription Factorsdirect conversionmyogenesisparaxial mesodermPax3

Identifiers

PMID32579865
PMCPMC7469637
OpenAlexW3036120403

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.