Evidence map›Paper›PMID 32579851›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2020

Influence of aminoacyl-tRNA synthetase complex-interacting multifunctional protein 1 on epithelial differentiation and organization during lung development.

Daniel D Lee, Alexandra Hochstetler, Eric Sah, Haiming Xu, Chinn-Woan Lowe, Sara Santiaguel, Janet Lea Thornton, Adam Pajakowski, Margaret A Schwarz

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Mechanistic regulation of SPHK1 expression and translocation by EMAP II in pulmonary smooth muscle cells.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Daniel D LeeDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, South Bend, Indiana.
Alexandra HochstetlerDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, South Bend, Indiana.
Eric SahDepartment of Applied and Computational Mathematics and Statistics, University of Notre Dame, South Bend, Indiana.
Haiming XuDepartment of Pediatrics, University of Texas-Southwestern, Dallas, Texas.
Chinn-Woan LoweDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, South Bend, Indiana.
Sara SantiaguelDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, South Bend, Indiana.
Janet Lea ThorntonDepartment of Pediatrics, University of Texas-Southwestern, Dallas, Texas.
Adam PajakowskiDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, South Bend, Indiana.
Margaret A SchwarzDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, South Bend, Indiana.
Indiana University School of MedicineThe University of Texas Southwestern Medical Center · USIndiana University · USUniversity of Notre Dame · US

Funding

Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
IU Training Program in Molecular Physiology and Clinical Mechanisms of Lung DiseaseT32HL091816 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Erick Forno, Roberto F. Machado · 2009 to 2026
$4.3M
EMAP II: Pulmonary Vascular MediatorR01HL114977 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SCHWARZ, MARGARET A · 2012 to 2015
$1.8M
Decoding Mediators in Lung DevelopmentR21HD090227 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI SCHWARZ, MARGARET A · 2018 to 2019
$433k
HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR001108NCATS NIH HHS UL1 TR001108NHLBI NIH HHS R01 HL114977NHLBI NIH HHS T32 HL091816NICHD NIH HHS R21 HD090227
6 · The paper itself

Abstract

Proper development of the respiratory bronchiole and alveolar epithelium proceeds through coordinated cross talk between the interface of epithelium and neighboring mesenchyme. Signals that facilitate and coordinate the cross talk as the bronchial forming canalicular stage transitions to construction of air-exchanging capillary-alveoli niche in the alveolar stage are poorly understood. Expressed within this decisive region, levels of aminoacyl-tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1) inversely correlate with the maturation of the lung. The present study addresses the role of AIMP1 in lung development through the generation and characterization of

Indexed as

ActinsAmino Acyl-tRNA SynthetasesAnimalsCell DifferentiationCell MembraneCytokinesEpithelial CellsFemaleIntercellular JunctionsLungMaleMiceMice, Inbred C57BLActinsAimp1 protein, mouseAmino Acyl-tRNA SynthetasesCytokinesAIMP1alveolarF-actinlung developmentphosphoinositide(s)

Identifiers

PMID32579851
PMCPMC7473932
OpenAlexW3037638797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.