Evidence map›Paper›PMID 32579570›Full record

SynthesisPloS one2020

Venous thromboembolism prevention in intracerebral hemorrhage: A systematic review and network meta-analysis.

Vignan Yogendrakumar, Ronda Lun, Faizan Khan, Kristin Salottolo, Karine Lacut, Catriona Graham, Martin Dennis, Brian Hutton, Philip S Wells, Dean Fergusson and 1 more

Open access · goldAbstract readSystematic ReviewNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Antithrombotic treatment after stroke due to intracerebral haemorrhage.The Cochrane database of systematic reviews · 2023
    Pooled it
  2. Article
  3. Clinical Management of Cerebral Amyloid Angiopathy.Journal of clinical medicine · 2025
    Review
  4. [In-hospital management of intracerebral hemorrhage].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025
    Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Vignan YogendrakumarDivision of Neurology, Department of Medicine, University of Ottawa, Ottawa, Canada.ORCID 0000-0001-8814-6853
Ronda LunDivision of Neurology, Department of Medicine, University of Ottawa, Ottawa, Canada.
Faizan KhanClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Kristin SalottoloTrauma Research Department, St. Anthony Hospital, Lakewood, Colorado, United States of America.
Karine LacutEA3878, Université de Bretagne Occidentale, Brest, France.
Catriona GrahamWellcome Trust Clinical Research Facility, Western General Hospital, Edinburgh, Scotland, United Kingdom.
Martin DennisCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Brian HuttonClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Philip S WellsDivision of Hematology, Department of Medicine, University of Ottawa, Ottawa, Canada.
Dean FergussonClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Dar DowlatshahiDivision of Neurology, Department of Medicine, University of Ottawa, Ottawa, Canada.
University of Ottawa · CAOttawa Hospital · CASt. Anthony Hospital · USUniversité de Bretagne Occidentale · FRUniversity of Edinburgh · GBWestern General Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTo summarize and compare the effectiveness of pharmacological thromboprophylaxis to pneumatic compression devices (PCD) for the prevention of venous thromboembolism in patients with acute intracerebral hemorrhage.

methodsMEDLINE, PUBMED, EMBASE, and CENTRAL were systematically searched to identify randomized and non-randomized studies that compared each intervention directly to each other or against a common control (hydration, anti-platelet agents, stockings) in adults with acute spontaneous intracerebral hemorrhage. Two investigators independently screened the studies, extracted data, and appraised risk of bias. Studies with a high risk of bias were excluded from our final analysis. The primary outcome was the occurrence of venous thromboembolism (proximal deep vein thrombosis or pulmonary embolism) in the first 30 days.

results8,739 articles were screened; four articles, all randomized control trials, met eligibility criteria. Bayesian network meta-analysis was performed to calculate risk estimates using both fixed and random effects analyses. 607 patients were included in the network analysis. PCD were associated with a significant decrease in venous thromboembolism compared to control (OR: 0.43, 95% Credible Limits [CrI]: 0.23-0.80). We did not find evidence of statistically significant differences between pharmacological thromboprophylaxis and control (OR: 0.93, 95% CrI: 0.19-4.37) or between PCD and pharmacological thromboprophylaxis (OR: 0.47, 95% CrI: 0.09-2.54).

conclusionPCDs are superior to control interventions, but meaningful comparisons with pharmacotherapy are not possible due to a lack of data. This requires further exploration via large pragmatic clinical trials.

trial registrationPROSPERO: CRD42018090960.

Indexed as

Cerebral HemorrhageHumansPublication BiasRiskVenous Thromboembolism

Identifiers

PMID32579570
PMCPMC7314010
OpenAlexW3037454767

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.