Evidence map›Paper›PMID 32579540›Full record

ArticleAging2020

Identification of an immune-related long non-coding RNA signature and nomogram as prognostic target for muscle-invasive bladder cancer.

Yuxuan Song, Donghui Jin, Jingyi Chen, Zhiwen Luo, Guangyuan Chen, Yongjiao Yang, Xiaoqiang Liu

Open access · greenAbstract readValidation Study
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Yuxuan SongDepartment of Urology, Tianjin Medical University General Hospital, Tianjin 300052, China.
Donghui JinDepartment of Cardiothoracic Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
Jingyi ChenDepartment of Gastroenterology and Institute of Clinical Molecular Biology, Peking University People's Hospital, Beijing 100044, China.
Zhiwen LuoDepartment of Hepatobiliary Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Guangyuan ChenThe Second Clinical Medical School, Nanchang University, Nanchang 330006, Jiangxi, China.
Yongjiao YangDepartment of Urology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China.
Xiaoqiang LiuDepartment of Urology, Tianjin Medical University General Hospital, Tianjin 300052, China.
Tianjin Medical University General Hospital · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNNanchang University · CNPeking University · CNSecond Hospital of Tianjin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To identify an immune-related prognostic signature based on long non-coding RNAs (lncRNAs) and find immunotherapeutic targets for bladder urothelial carcinoma, we downloaded RNA-sequencing data from The Cancer Genome Atlas (TCGA) dataset. Functional enrichment analysis demonstrated bladder urothelial carcinoma was related to immune-related functions. We obtained 332 immune-related genes and 262 lncRNAs targeting immune-related genes. We constructed a signature based on eight lncRNAs in training cohort. Patients were classified as high-risk and low-risk according to signature risk score. High-risk patients had poor overall survival compared with low-risk patients (

Indexed as

NomogramsAgedBiomarkers, TumorCarcinoma, Transitional CellCathepsin GChemokine CXCL12Datasets as TopicDNA Ligase ATPFemaleFollow-Up StudiesGene Expression Regulation, NeoplasticHumansImmunohistochemistryKaplan-Meier EstimateMaleMiddle AgedBiomarkers, TumorCathepsin GChemokine CXCL12CTSG protein, humanCXCL12 protein, humanDNA Ligase ATPLIG1 protein, humanRNA, Long NoncodingT-Box Domain ProteinsTBX1 protein, humanimmune-relatedlncRNA signaturemuscle-invasive bladder cancernomogramprognostic model

Identifiers

PMID32579540
PMCPMC7343518
OpenAlexW3037271636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.