ArticleeLife2020
Echinoderms provide missing link in the evolution of PrRP/sNPF-type neuropeptide signalling.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Molecular evidence for early deuterostome origins of ovarian cell types and neuroendocrine control of reproduction.Nature communications · 2026Article
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- Discovery and functional characterization of a bombesin-type neuropeptide signaling system in an invertebrate.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Synaptic connectome of a neurosecretory network in thebioRxiv : the preprint server for biology · 2024Article
- Research Progress on Starfish Outbreaks and Their Prevention and Utilization: Lessons from Northern China.Biology · 2024Review
- Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans.Molecular and cellular endocrinology · 2024Article
- Chromosomal-level genome assembly of the long-spined sea urchinGigaByte (Hong Kong, China) · 2024Article
- System-wide mapping of peptide-GPCR interactions in C. elegans.Cell reports · 2023Article
- On the origin of appetite: GLWamide in jellyfish represents an ancestral satiety neuropeptide.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Receptor deorphanization in an echinoderm reveals kisspeptin evolution and relationship with SALMFamide neuropeptides.BMC biology · 2022Article
- Premetazoan Origin of Neuropeptide Signaling.Molecular biology and evolution · 2022Article
- Reconstructing the Origins of the Somatostatin and Allatostatin-C Signaling Systems Using the Accelerated Evolution of Biodiverse Cone Snail Toxins.Molecular biology and evolution · 2022Article
- Somatostatin-type and allatostatin-C-type neuropeptides are paralogous and have opposing myoregulatory roles in an echinoderm.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Discovery and functional characterization of neuropeptides in crinoid echinoderms.Frontiers in neuroscience · 2022Article
- Functional analysis of LFRFamide signaling in Pacific abalone, Haliotis discus hannai.PloS one · 2022Article
- Nemertean, Brachiopod, and Phoronid Neuropeptidomics Reveals Ancestral Spiralian Signaling Systems.Molecular biology and evolution · 2021Article
- NPF activates a specific NPF receptor and regulates food intake in Pacific abalone Haliotis discus hannai.Scientific reports · 2021Article
- Article
- Identification of the neuropeptide precursor genes potentially involved in the larval settlement in the Echiuran worm Urechis unicinctus.BMC genomics · 2020Article
- NPY/NPF-Related Neuropeptide FLP-34 Signals from Serotonergic Neurons to Modulate Aversive Olfactory Learning inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Neuropeptide signalling systems comprising peptide ligands and cognate receptors are evolutionarily ancient regulators of physiology and behaviour. However, there are challenges associated with determination of orthology between neuropeptides in different taxa. Orthologs of vertebrate neuropeptide-Y (NPY) known as neuropeptide-F (NPF) have been identified in protostome invertebrates, whilst prolactin-releasing peptide (PrRP) and short neuropeptide-F (sNPF) have been identified as paralogs of NPY/NPF in vertebrates and protostomes, respectively. Here we investigated the occurrence of NPY/NPF/PrRP/sNPF-related signalling systems in a deuterostome invertebrate phylum - the Echinodermata. Analysis of transcriptome/genome sequence data revealed loss of NPY/NPF-type signalling, but orthologs of PrRP-type neuropeptides and sNPF/PrRP-type receptors were identified in echinoderms. Furthermore, experimental studies revealed that the PrRP-type neuropeptide pQDRSKAMQAERTGQLRRLNPRF-NH
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