Evidence map›Paper›PMID 32579483›Full record

Trial reportThe Journal of international medical research2020

Protective effect of dexmedetomidine infusion combined with epidural blockade on postoperative complications after surgery: A prospective randomized controlled clinical trial.

Yi Liu, Xuqin Zhu, Zhiyong He, Zhirong Sun, Xin Wu, Jing Zhong

RetractedOpen access · goldAbstract readRandomized Controlled TrialRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 12 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 7 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 7 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  10. Retraction.The Journal of international medical research · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yi LiuDepartment of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, China.
Xuqin ZhuDepartment of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, China.
Zhiyong HeDepartment of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, China.
Zhirong SunDepartment of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, China.
Xin WuDepartment of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, China.
Jing ZhongDepartment of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, China.ORCID https://orcid.org/0000-0001-8673-9065
Shanghai Medical College of Fudan University · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis prospective, randomized, controlled study aimed to explore the efficacy of dexmedetomidine combined with epidural blockade on postoperative recovery of elderly patients after radical resection for colorectal cancer.

methodsNinety-six elderly patients who underwent radical resection for colorectal cancer were randomly divided into the following four groups: dexmedetomidine, epidural blockade (ropivacaine), combined (dexmedetomidine + epidural blockade), and control (0.9% saline). The Mini-Mental State Examination (MMSE), Visual Analog Scale (VAS), and Ramsay scores at 48 hours, and time to first activity, length of hospital stay, and postoperative complication rates at 3 months were assessed.

resultsTwelve hours after surgery, Ramsay scores were higher in the combined compared with the control and epidural blockade groups. Twenty-four hours after surgery, MMSE scores were higher in the combined compared with the other groups. The combined group showed the lowest VAS scores except at 48 hours. Time to first activity and length of hospital stay were significantly shorter in the combined compared with the other groups. There was no difference in total postoperative complication rates among the groups.

conclusionsA combination of intraoperative dexmedetomidine infusion and epidural blockade could mitigate pain after surgery, improve cognitive dysfunction in early surgery, and facilitate recovery.

Indexed as

AgedAged, 80 and overAnalgesia, Patient-ControlledAnalgesics, Non-NarcoticAnalgesics, OpioidAnesthesia, EpiduralChinaDexmedetomidineFemaleHumansInfusions, ParenteralMalePain MeasurementPostoperative PainProspective StudiesRopivacaineAnalgesics, Non-NarcoticAnalgesics, OpioidDexmedetomidineRopivacainecognitive dysfunctionColorectal cancerdexmedetomidineepiduralMini-Mental State Examination (MMSE)pain managementRamsay scoreVisual Analog Scale (VAS)

Identifiers

PMID32579483
PMCPMC7315680
OpenAlexW3037358463

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.