Evidence map›Paper›PMID 32579470›Full record

ArticleGut microbes2020

Germ-free housing conditions do not affect aortic root and aortic arch lesion size of late atherosclerotic low-density lipoprotein receptor-deficient mice.

Klytaimnistra Kiouptsi, Giulia Pontarollo, Hristo Todorov, Johannes Braun, Sven Jäckel, Thomas Koeck, Franziska Bayer, Cornelia Karwot, Angelica Karpi, Susanne Gerber and 8 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Diet-gut microbiota interactions on cardiovascular disease.Computational and structural biotechnology journal · 2022
    Review
  7. Article
  8. Review
  9. Review
  10. The microbiome and rodent models of immune mediated diseases.Mammalian genome : official journal of the International Mammalian Genome Society · 2021
    Review
  11. Article
  12. Review
  13. The Commensal Microbiota Enhances ADP-Triggered Integrin αInternational journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 4 countries.

Klytaimnistra KiouptsiCenter for Thrombosis and Hemostasis (CTH), University Medical Center Mainz , Mainz, Germany.ORCID 0000-0002-8076-5040
Giulia PontarolloCenter for Thrombosis and Hemostasis (CTH), University Medical Center Mainz , Mainz, Germany.ORCID 0000-0002-6783-8241
Hristo TodorovInstitute of Developmental Biology and Neurobiology, University Medical Center of the Johannes Gutenberg University of Mainz , Mainz, Germany.ORCID 0000-0003-2734-7701
Johannes BraunCenter for Thrombosis and Hemostasis (CTH), University Medical Center Mainz , Mainz, Germany.
Sven JäckelCenter for Thrombosis and Hemostasis (CTH), University Medical Center Mainz , Mainz, Germany.
Thomas KoeckCenter for Thrombosis and Hemostasis (CTH), University Medical Center Mainz , Mainz, Germany.
Franziska BayerCenter for Thrombosis and Hemostasis (CTH), University Medical Center Mainz , Mainz, Germany.
Cornelia KarwotCenter for Thrombosis and Hemostasis (CTH), University Medical Center Mainz , Mainz, Germany.
Angelica KarpiCenter for Cardiology, Cardiology I, University Medical Center Mainz , Mainz, Germany.
Susanne GerberInstitute of Developmental Biology and Neurobiology, University Medical Center of the Johannes Gutenberg University of Mainz , Mainz, Germany.ORCID 0000-0001-9513-0729
Yvonne JansenInstitute of Cardiovascular Prevention, Department of Medicine, Ludwig-Maximilians-University Munich , Munich, Germany.
Philipp WildCenter for Thrombosis and Hemostasis (CTH), University Medical Center Mainz , Mainz, Germany.ORCID 0000-0003-4413-9752
Wolfram RufCenter for Thrombosis and Hemostasis (CTH), University Medical Center Mainz , Mainz, Germany.ORCID 0000-0002-6064-2166
Andreas DaiberGerman Center for Cardiovascular Research (DZHK), Partner Site RheinMain , Mainz, Germany.ORCID 0000-0002-2769-0094
Emiel Van Der VorstInstitute of Cardiovascular Prevention, Department of Medicine, Ludwig-Maximilians-University Munich , Munich, Germany.ORCID 0000-0001-5771-6278
Christian WeberInstitute of Cardiovascular Prevention, Department of Medicine, Ludwig-Maximilians-University Munich , Munich, Germany.ORCID 0000-0003-4610-8714
Yvonne DöringInstitute of Cardiovascular Prevention, Department of Medicine, Ludwig-Maximilians-University Munich , Munich, Germany.ORCID 0000-0001-9307-3396
Christoph ReinhardtCenter for Thrombosis and Hemostasis (CTH), University Medical Center Mainz , Mainz, Germany.ORCID 0000-0002-0696-2636
Johannes Gutenberg University Mainz · DEGerman Centre for Cardiovascular Research · DELudwig-Maximilians-Universität München · DEMaastricht University · NLScripps Research Institute · USUniversity Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The microbiota has been linked to the development of atherosclerosis, but the functional impact of these resident bacteria on the lesion size and cellular composition of atherosclerotic plaques in the aorta has never been experimentally addressed with the germ-free low-density lipoprotein receptor-deficient (

Indexed as

AnimalsAorta, ThoracicDisease Models, AnimalFemaleGerm-Free LifeHousing, AnimalHumansMaleMiceMice, Inbred C57BLMice, KnockoutMicrobiotaPlaque, AtheroscleroticReceptors, LDLReceptors, LDLageaortic archaortic rootatherosclerosisgerm-freeinflammatory markerslesion sizelow-density lipoprotein receptor-deficient mousemacrophagesMicrobiotasmooth muscle cells

Identifiers

PMID32579470
PMCPMC7524356
OpenAlexW3037773911

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.