Evidence map›Paper›PMID 32579427›Full record

ArticleMolecular biology of the cell2020

Touch-induced mechanical strain in somatosensory neurons is independent of extracellular matrix mutations in

Adam L Nekimken, Beth L Pruitt, Miriam B Goodman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Adam L NekimkenDepartments of Mechanical Engineering, Stanford University, Stanford, CA 94305.
Beth L PruittDepartments of Mechanical Engineering, Stanford University, Stanford, CA 94305.
Miriam B GoodmanDepartments of Mechanical Engineering, Stanford University, Stanford, CA 94305.
Stanford University · USUniversity of California, Santa Barbara · US

Funding

The biophysics of skin-neuron sensory tactile organs and their sensitivity to mechanical and chemical stressR35NS105092 · NINDS · STANFORD UNIVERSITY · PI GOODMAN, MIRIAM B · 2018 to 2025
$6.4M
High Throughput DNA Sequencer UpgradeS10OD018220 · OD · STANFORD UNIVERSITY · PI COLLER, JOHN · 2014 to 2014
$596k
Internal Tissue Mechanics and the Sense of Touch in C. elegansF31NS100318 · NINDS · STANFORD UNIVERSITY · PI NEKIMKEN, ADAM · 2017 to 2019
$106k
National Science Foundation ECCS-1542152NIH HHS S10 OD018220NINDS NIH HHS F31 NS100318NINDS NIH HHS R35 NS105092
6 · The paper itself

Abstract

Cutaneous mechanosensory neurons are activated by mechanical loads applied to the skin, and these stimuli are proposed to generate mechanical strain within sensory neurons. Using a microfluidic device to deliver controlled stimuli to intact animals and large, immobile, and fluorescent protein-tagged mitochondria as fiducial markers in the touch receptor neurons (TRNs), we visualized and measured touch-induced mechanical strain in

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsExtracellular MatrixMechanoreceptorsMechanotransduction, CellularMembrane ProteinsSensory Receptor CellsTouchCaenorhabditis elegans ProteinsMembrane Proteins

Identifiers

PMID32579427
PMCPMC7521855
OpenAlexW3037058360

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.