ArticleJournal of neurophysiology2020
Delta oscillations are a robust biomarker of dopamine depletion severity and motor dysfunction in awake mice.
Article in Journal of neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Differential effects of hormone therapy formulations on Parkinson's disease risk: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Clinical Effect on Cortical Reactivity of Theta Burst Versus High-Frequency Repetitive Transcranial Magnetic Stimulation in Parkinson's Disease: A TMS-EEG Study.CNS neuroscience & therapeutics · 2025Trial
- Dynamic neural states underpin motor symptom severity in Parkinson's disease: a longitudinal analysis of chronic cortico-subthalamic nucleus recordings.EBioMedicine · 2026Article
- Exercise evokes retained motor performance without neuroprotection in a mouse model of Parkinson's disease.Frontiers in physiology · 2026Article
- A Distributed Oscillatory Network Model of Parkinsonian Tremor: Integrating Basal Ganglia and Cerebello-Thalamic Circuits.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Review
- Cellular and synaptic properties of molecularly defined neurons in the external globus pallidus.iScience · 2025Article
- Parkinsonism disrupts cortical function by dysregulating oscillatory, network and synaptic activity of parvalbumin positive interneurons.NPJ Parkinson's disease · 2025Article
- The Effect of Dopaminergic Therapy in Parkinson's Disease: A Graph Theory Analysis.Brain sciences · 2025Article
- Motor learning leverages coordinated low-frequency cortico-basal ganglia activity to optimize motor preparation in humans with Parkinson's disease.Frontiers in neuroscience · 2025Article
- Deep-learning-optimized microstate network analysis for early Parkinson's disease with mild cognitive impairment.Cognitive neurodynamics · 2024Article
- Transient Increases in Neural Oscillations and Motor Deficits in a Mouse Model of Parkinson's Disease.International journal of molecular sciences · 2024Article
- Detecting rhythmic spiking through the power spectra of point process model residuals.Journal of neural engineering · 2024Article
- Detecting rhythmic spiking through the power spectra of point process model residuals.bioRxiv : the preprint server for biology · 2024Article
- Role of HCN channels in the functions of basal ganglia and Parkinson's disease.Cellular and molecular life sciences : CMLS · 2024Review
- Knocking out the LRRK2 gene increases sensitivity to wavelength information in rats.Scientific reports · 2024Article
- Synaptic Changes in Pallidostriatal Circuits Observed in the Parkinsonian Model Triggers Abnormal Beta Synchrony with Accurate Spatio-temporal Properties across the Basal Ganglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Dopamine depletion leads to pathological synchronization of distinct basal ganglia loops in the beta band.PLoS computational biology · 2023Article
- Transmission of delta band (0.5-4 Hz) oscillations from the globus pallidus to the substantia nigra pars reticulata in dopamine depletion.Journal of computational neuroscience · 2022Article
- Historical and Modern Evidence for the Role of Reward Circuitry in Emergence.Anesthesiology · 2022Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Delta oscillations (0.5-4 Hz) are a robust feature of basal ganglia pathophysiology in patients with Parkinson's disease (PD) in relationship to tremor, but their relationship to other parkinsonian symptoms has not been investigated. While delta oscillations have been observed in mouse models of PD, they have only been investigated in anesthetized animals, suggesting that the oscillations may be an anesthesia artifact and limiting the ability to relate them to motor symptoms. Here, we establish a novel approach to detect spike oscillations embedded in noise to provide the first study of delta oscillations in awake, dopamine-depleted mice. We find that approximately half of neurons in the substantia nigra pars reticulata (SNr) exhibit delta oscillations in dopamine depletion and that these oscillations are a strong indicator of dopamine loss and akinesia, outperforming measures such as changes in firing rate, irregularity, bursting, and synchrony. These oscillations are typically weakened, but not ablated, during movement. We further establish that these oscillations are caused by the loss of D2-receptor activation and do not originate from motor cortex, contrary to previous findings in anesthetized animals. Instead, SNr oscillations precede those in M1 at a 100- to 300-ms lag, and these neurons' relationship to M1 oscillations can be used as the basis for a novel classification of SNr into two subpopulations. These results give insight into how dopamine loss leads to motor dysfunction and suggest a reappraisal of delta oscillations as a marker of akinetic symptoms in PD.
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Registered trials
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