Evidence map›Paper›PMID 32579419›Full record

ReviewInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group2020

Heating technology for malignant tumors: a review.

H Petra Kok, Erik N K Cressman, Wim Ceelen, Christopher L Brace, Robert Ivkov, Holger Grüll, Gail Ter Haar, Peter Wust, Johannes Crezee

Abstract readReview
In one paragraph

Review in International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers.

0numbers the graph read from it
0cells of the map it votes in
141citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

141 citing papers in PubMed.

  1. Review
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  7. Successful palliative hypofractionated radiotherapy with superficial hyperthermia for heavily pretreated cutaneous breast cancer lesions.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Article
  8. Review
  9. Capacitive heating devices for therapeutic hyperthermia: a review of essential physical characteristics and challenges.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Review
  10. Article
  11. Review
  12. Article
  13. Article
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  16. Review
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  20. Article

81 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

H Petra KokDepartment of Radiation Oncology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-8504-136X
Erik N K CressmanDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wim CeelenDepartment of GI Surgery, Ghent University Hospital, Ghent, Belgium.ORCID 0000-0001-7692-4419
Christopher L BraceDepartment of Radiology and Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-6777-6554
Robert IvkovDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-2930-5276
Holger GrüllDepartment of Diagnostic and Interventional Radiology, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany.
Gail Ter HaarDepartment of Physics, The Institute of Cancer Research, London, UK.
Peter WustDepartment of Radiation Oncology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Johannes CrezeeDepartment of Radiation Oncology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-7474-0533

Funding

Translational Application of Magnetic Hyperthermia Therapy with Adjuvant Therapies for GlioblastomaR01CA247290 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HADJIPANAYIS, CONSTANTINOS GEORGE, IVKOV, ROBERT · 2020 to 2024
$3.5M
Enhancing Liver Cancer Treatment With Image-Guided Magnetic HyperthermiaR01CA194574 · NCI · JOHNS HOPKINS UNIVERSITY · PI IVKOV, ROBERT · 2015 to 2019
$3.2M
NCI NIH HHS R01 CA194574NCI NIH HHS R01 CA247290
6 · The paper itself

Abstract

The therapeutic application of heat is very effective in cancer treatment. Both hyperthermia, i.e., heating to 39-45 °C to induce sensitization to radiotherapy and chemotherapy, and thermal ablation, where temperatures beyond 50 °C destroy tumor cells directly are frequently applied in the clinic. Achievement of an effective treatment requires high quality heating equipment, precise thermal dosimetry, and adequate quality assurance. Several types of devices, antennas and heating or power delivery systems have been proposed and developed in recent decades. These vary considerably in technique, heating depth, ability to focus, and in the size of the heating focus. Clinically used heating techniques involve electromagnetic and ultrasonic heating, hyperthermic perfusion and conductive heating. Depending on clinical objectives and available technology, thermal therapies can be subdivided into three broad categories: local, locoregional, or whole body heating. Clinically used local heating techniques include interstitial hyperthermia and ablation, high intensity focused ultrasound (HIFU), scanned focused ultrasound (SFUS), electroporation, nanoparticle heating, intraluminal heating and superficial heating. Locoregional heating techniques include phased array systems, capacitive systems and isolated perfusion. Whole body techniques focus on prevention of heat loss supplemented with energy deposition in the body, e.g., by infrared radiation. This review presents an overview of clinical hyperthermia and ablation devices used for local, locoregional, and whole body therapy. Proven and experimental clinical applications of thermal ablation and hyperthermia are listed. Methods for temperature measurement and the role of treatment planning to control treatments are discussed briefly, as well as future perspectives for heating technology for the treatment of tumors.

Indexed as

Hyperthermia, InducedNeoplasmsHeatingHot TemperatureHumansTechnologyablationheating equipmentHIPEChyhperthermiathermal therapy

Identifiers

PMID32579419
PMCPMC7781160

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.