Evidence map›Paper›PMID 32579326›Full record

ArticleACS infectious diseases2020

A Clerodane Diterpene from

Micah Dettweiler, Roberta J Melander, Gina Porras, Caitlin Risener, Lewis Marquez, Tharanga Samarakoon, Christian Melander, Cassandra L Quave

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Pharmacophylogenetic relationships of genusFrontiers in pharmacology · 2024
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. BuildingNatural product reports · 2021
    Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Micah DettweilerEmory University, Department of Dermatology, 615 Michael Street, Whitehead 105L, Atlanta, Georgia 30322, United States.
Roberta J MelanderDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Gina PorrasEmory University, Center for the Study of Human Health, 1557 Dickey Drive, Anthropology 306, Atlanta, Georgia 30322, United States.
Caitlin RisenerEmory University, Molecular and Systems Pharmacology Program, 615 Michael Street, Whitehead 115, Atlanta, Georgia 30322, United States.
Lewis MarquezEmory University, Molecular and Systems Pharmacology Program, 615 Michael Street, Whitehead 115, Atlanta, Georgia 30322, United States.
Tharanga SamarakoonEmory University Herbarium, 1462 Clifton Road, Atlanta, Georgia 30322, United States.
Christian MelanderDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID 0000-0001-8271-4696
Cassandra L QuaveEmory University, Department of Dermatology, 615 Michael Street, Whitehead 105L, Atlanta, Georgia 30322, United States.ORCID 0000-0001-9615-7886
Emory University · USUniversity of Notre Dame · US

Funding

Graduate Training in the Pharmacological StudiesT32GM008602 · NIGMS · EMORY UNIVERSITY · PI HALL, RANDY A. · 1996 to 2021
$5.1M
SMALL MOLECULE INHIBITORS OF CARIOGENIC BIOFILMSR01DE022350 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Christian Corey Melander, Hui Wu · 2012 to 2026
$4.3M
Novel compounds from botanical innovation yields Acinetobacter treatmentsR21AI136563 · NIAID · EMORY UNIVERSITY · PI QUAVE, CASSANDRA LEAH · 2018 to 2019
$443k
NIAID NIH HHS R21 AI136563NIDCR NIH HHS R01 DE022350NIGMS NIH HHS T32 GM008602
6 · The paper itself

Abstract

The rise of antibiotic resistance presents a significant healthcare challenge and precludes the use of many otherwise valuable antibiotics. One potential solution to this problem is the use of antibiotics in combination with resistance-modifying agents, compounds that act synergistically with existing antibiotics to resensitize previously resistant bacteria. In this study, 12(

Indexed as

CallicarpaDiterpenes, ClerodaneMethicillin-Resistant Staphylococcus aureusAnti-Bacterial AgentsDrug SynergismMicrobial Sensitivity TestsOxacillinStaphylococcus aureusAnti-Bacterial AgentsDiterpenes, ClerodaneOxacillinbotanicalMRSAnatural productoxacillinsynergyterpene

Identifiers

PMID32579326
PMCPMC8183163
OpenAlexW3037293482

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.