Evidence map›Paper›PMID 32579262›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2020

Enzymatic Insertion of Lipids Increases Membrane Tension for Inhibiting Drug Resistant Cancer Cells.

Jiaqing Wang, Weiyi Tan, Guanying Li, Difei Wu, Hongjian He, Jiashu Xu, Meihui Yi, Ye Zhang, S Ali Aghvami, Seth Fraden and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Synthesis and bioactivity of pyrrole-conjugated phosphopeptides.Beilstein journal of organic chemistry · 2022
    Article
  8. Article
  9. Article
  10. Enzymatic Noncovalent Synthesis.Chemical reviews · 2020
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Jiaqing WangDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, MA, 02453, USA.ORCID http://orcid.org/0000-0003-4405-9496
Weiyi TanDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, MA, 02453, USA.
Guanying LiBioinspired Soft Matter Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Okinawa, 904-0495, Japan.
Difei WuDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, MA, 02453, USA.
Hongjian HeDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, MA, 02453, USA.
Jiashu XuDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, MA, 02453, USA.
Meihui YiDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, MA, 02453, USA.
Ye ZhangBioinspired Soft Matter Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Okinawa, 904-0495, Japan.
S Ali AghvamiDepartment of Physic, Brandeis University, 415 South Street, Waltham, MA, 02453, USA.
Seth FradenDepartment of Physic, Brandeis University, 415 South Street, Waltham, MA, 02453, USA.
Bing XuDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, MA, 02453, USA.ORCID http://orcid.org/0000-0002-4639-387X
Brandeis University · USOkinawa Institute of Science and Technology Graduate University · JP

Funding

Subcellular Enzyme-instructed self-assembly for molecular anticancer nanomedicinesR01CA142746 · NCI · BRANDEIS UNIVERSITY · PI Bing Xu · 2010 to 2026
$6.4M
National Institute of Health R01CA142746National Science Foundation DMR-2011846NCI NIH HHS R01 CA142746
6 · The paper itself

Abstract

Although lipids contribute to cancer drug resistance, it is challenging to target diverse range of lipids. Here, we show enzymatically inserting exceedingly simple synthetic lipids into membranes for increasing membrane tension and selectively inhibiting drug resistant cancer cells. The lipid, formed by conjugating dodecylamine to d-phosphotyrosine, self-assembles to form micelles. Enzymatic dephosphorylation of the micelles inserts the lipids into membranes and increases membrane tension. The micelles effectively inhibit a drug resistant glioblastoma cell (T98G) or a triple-negative breast cancer cell (HCC1937), without inducing acquired drug resistance. Moreover, the enzymatic reaction of the micelles promotes the accumulation of the lipids in the membranes of subcellular organelles (e.g., endoplasmic reticulum (ER), Golgi, and mitochondria), thus activating multiple regulated cell death pathways. This work, in which for the first time membrane tension is increased to inhibit cancer cells, illustrates a new and powerful supramolecular approach for antagonizing difficult drug targets.

Indexed as

NeoplasmsPharmaceutical PreparationsCell Line, TumorDrug Resistance, NeoplasmEndoplasmic ReticulumHumansLipidsLipidsPharmaceutical Preparationscancer cellsdrug resistanceenzymatic insertionlipidsmembrane tension

Identifiers

PMID32579262
PMCPMC7821352
OpenAlexW3037004356

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.