ArticleChemistry (Weinheim an der Bergstrasse, Germany)2021
Total Synthesis of a Partial Structure from Arabinogalactan and Its Application for Allergy Prevention.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 9 citations in OpenAlex.
- Benzoylation of Tetrols: A Comparison of Regioselectivity Patterns forThe Journal of organic chemistry · 2024Article
- Total Synthesis of a Partial Structure from Arabinogalactan and Its Application for Allergy Prevention.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
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11 authors at 4 institutions in 1 country.
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Abstract
Arabinogalactan, a microheterogeneous polysaccharide occurring in plants, is known for its allergy-protective activity, which could potentially be used for preventive allergy treatment. New treatment options are highly desirable, especially in a preventive manner, due to the constant rise of atopic diseases worldwide. The structural origin of the allergy-protective activity of arabinogalactan is, however, still unclear and isolation of the polysaccharide is not feasible for pharmaceutical applications due to a variation of the activity of the natural product and contaminations with endotoxins. Therefore, a pentasaccharide partial structure was selected for total synthesis and subsequently coupled to a carrier protein to form a neoglycoconjugate. The allergy-protective activity of arabinogalactan could be reproduced with the partial structure in subsequent in vivo experiments. This is the first example of a successful simplification of arabinogalactan with a single partial structure while retaining its allergy-preventive potential.
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