ArticleeLife2020
Control of adaptive action selection by secondary motor cortex during flexible visual categorization.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
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- Association of Altered V1-M2 Neuronal Activation with Balance and Coordination Deficits in a Corneal Alkali Burn Mouse Model of Visual Impairment.Brain sciences · 2026Article
- The Secondary Motor Cortex-External Globus Pallidus Pathway Regulates Auditory Feedback of Volitional Control.Neuroscience bulletin · 2026Article
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- Prediction-error signals in anterior cingulate cortex drive task-switching.Nature communications · 2024Article
- Single-Trial Representations of Decision-Related Variables by Decomposed Frontal Corticostriatal Ensemble Activity.eNeuro · 2024Article
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- The secondary somatosensory cortex gates mechanical and heat sensitivity.Nature communications · 2024Article
- The Secondary Motor Cortex-striatum Circuit Contributes to Suppressing Inappropriate Responses in Perceptual Decision Behavior.Neuroscience bulletin · 2023Article
- M2 Cortex Circuitry and Sensory-Induced Behavioral Alterations in Huntington's Disease: Role of Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Carboxypeptidase E conditional knockout mice exhibit learning and memory deficits and neurodegeneration.Translational psychiatry · 2023Article
- Influence of Recent Trial History on Interval Timing.Neuroscience bulletin · 2023Article
- Neural Mechanisms That Make Perceptual Decisions Flexible.Annual review of physiology · 2023Review
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- Prospective and retrospective values integrated in frontal cortex drive predictive choice.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Stress induces microglia-associated synaptic circuit alterations in the dorsomedial prefrontal cortex.Neurobiology of stress · 2021Article
- Dynamics of history-dependent perceptual judgment.Nature communications · 2021Article
- Secondary motor cortex: Broadcasting and biasing animal's decisions through long-range circuits.International review of neurobiology · 2021Review
- Control of adaptive action selection by secondary motor cortex during flexible visual categorization.eLife · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Adaptive action selection during stimulus categorization is an important feature of flexible behavior. To examine neural mechanism underlying this process, we trained mice to categorize the spatial frequencies of visual stimuli according to a boundary that changed between blocks of trials in a session. Using a model with a dynamic decision criterion, we found that sensory history was important for adaptive action selection after the switch of boundary. Bilateral inactivation of the secondary motor cortex (M2) impaired adaptive action selection by reducing the behavioral influence of sensory history. Electrophysiological recordings showed that M2 neurons carried more information about upcoming choice and previous sensory stimuli when sensorimotor association was being remapped than when it was stable. Thus, M2 causally contributes to flexible action selection during stimulus categorization, with the representations of upcoming choice and sensory history regulated by the demand to remap stimulus-action association.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.