Evidence map›Paper›PMID 32579056›Full record

ArticleAdipocyte2020

TSH promotes adiposity by inhibiting the browning of white fat.

Jianmei Zhang, Huixiao Wu, Shizhan Ma, Ling Gao, Chunxiao Yu, Fei Jing, Jiajun Zhao

Open access · goldAbstract read
In one paragraph

Article in Adipocyte, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Endocrine-Metabolic Crosstalk Between Diabetes Mellitus and Hypothyroidism: From Network Mechanisms to Translational Stratification.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  2. Review
  3. Global loss of selenocysteine lyase in mice drives lipid accumulation in brown adipocytes.American journal of physiology. Endocrinology and metabolism · 2026
    Article
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  5. Review
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  15. Article
  16. Obesity and Thyroid Axis.International journal of environmental research and public health · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jianmei ZhangDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University , Shandong, P.R. China.
Huixiao WuDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University , Shandong, P.R. China.
Shizhan MaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University , Shandong, P.R. China.
Ling GaoDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University , Shandong, P.R. China.
Chunxiao YuDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University , Shandong, P.R. China.
Fei JingDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University , Shandong, P.R. China.
Jiajun ZhaoDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University , Shandong, P.R. China.
Shandong First Medical University · CNShandong Provincial Hospital · CNWeihai Municipal Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adiposity is caused by an imbalance between energy intake and consumption. Promotion of the browning of white fat increases energy expenditure and could combat adiposity. Thyroid-stimulating hormone (TSH) has been confirmed to positively correlate with adiposity. However, the putative connection between TSH and white adipose browning has never been explored. In this study, we sought to assess the effect of TSH on white adipose tissue browning and energy metabolism. Subclinical hypothyroidism mice, thyroid-specific

Indexed as

AdiposityAdipocytes, BrownAdipogenesisAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsBiomarkersCell DifferentiationEnergy MetabolismMaleMetabolic DiseasesMiceMice, TransgenicReceptors, ThyrotropinThermogenesisThyrotropinBiomarkersReceptors, ThyrotropinThyrotropinAdiposityAMPKbrowningPGC1ΑPRDM16TSH

Identifiers

PMID32579056
PMCPMC7469524
OpenAlexW3038034544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.