Evidence map›Paper›PMID 32578977›Full record

ReviewACS chemical neuroscience2020

Classics in Neuroimaging: Development of Positron Emission Tomography Tracers for Imaging the GABAergic Pathway.

Emily Murrell, Jonathan M Pham, Alexandra R Sowa, Allen F Brooks, Michael R Kilbourn, Peter J H Scott, Neil Vasdev

Open access · greenAbstract readReview
In one paragraph

Review in ACS chemical neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Potential TMS biomarkers for GABAAlcohol, clinical & experimental research · 2025
    Pooled it
  2. Pathophysiology and Prognostic Significance of Myoclonus in Hypoxic-Ischemic Encephalopathy.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2026
    Review
  3. Article
  4. Review
  5. Toward Imaging of the GABA Transporter Type 1 In Vivo: Quantitative Evaluation of 4 Novel PET Radiotracers in Nonhuman Primates.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  6. Article
  7. Synthesis and Evaluation of BenzylicACS chemical neuroscience · 2025
    Article
  8. Review
  9. GABAFrontiers in neuroscience · 2023
    Article
  10. Article
  11. A Brief History and the Significance of the GABACurrent topics in behavioral neurosciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Emily MurrellAzrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Centre for Addiction and Mental Health & Department of Psychiatry, University of Toronto, Toronto, Ontario M5T-1R8, Canada.
Jonathan M PhamDepartment of Radiology, University of Michigan, 1301 Catherine Street, Ann Arbor, Michigan 48109, United States.
Alexandra R SowaDepartment of Radiology, University of Michigan, 1301 Catherine Street, Ann Arbor, Michigan 48109, United States.
Allen F BrooksDepartment of Radiology, University of Michigan, 1301 Catherine Street, Ann Arbor, Michigan 48109, United States.ORCID 0000-0003-3773-3024
Michael R KilbournDepartment of Radiology, University of Michigan, 1301 Catherine Street, Ann Arbor, Michigan 48109, United States.ORCID 0000-0003-4100-4676
Peter J H ScottDepartment of Radiology, University of Michigan, 1301 Catherine Street, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-6505-0450
Neil VasdevAzrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Centre for Addiction and Mental Health & Department of Psychiatry, University of Toronto, Toronto, Ontario M5T-1R8, Canada.ORCID 0000-0002-2087-5125
University of Michigan · USCentre for Addiction and Mental Health · CA

Funding

Translation of tau-selective PET radiopharmaceuticals in Alzheimers patientsR01AG052414 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI PRICE, JULIE C, VASDEV, NEIL · 2018 to 2021
$2.7M
Neuro-PET Radiotracer Discovery for Imaging Glycogen Synthase Kinase-3R01AG054473 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI VASDEV, NEIL · 2017 to 2020
$1.7M
Radioligands for PET Imaging of GABA TransportersR21NS086758 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KILBOURN, MICHAEL R · 2014 to 2015
$427k
NIA NIH HHS R01 AG052414NIA NIH HHS R01 AG054473NINDS NIH HHS R21 NS086758
6 · The paper itself

Abstract

Advances in drug discovery and diverse radiochemical methodologies have led to the discovery of novel positron emission tomography (PET) radiotracers used to image the GABAergic system, shaping our fundamental understanding of a variety of brain health illnesses, including epilepsy, stroke, cerebral palsy, schizophrenia, autism, Alzheimer's disease, and addictions. In this Viewpoint, we review the state-of-the art of PET imaging with radiotracers that target the GABA

Indexed as

Positron-Emission TomographyRadiopharmaceuticalsBrainNeuroimagingRadiochemistryReceptors, GABA-BRadiopharmaceuticalsReceptors, GABA-Bbenzodiazepinecarbon-11fluorine-18GABAPET

Identifiers

PMID32578977
PMCPMC7982716
OpenAlexW3037324199

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.