ArticleMolecular genetics & genomic medicine2020
Different prevalence of T2DM risk alleles in Roma population in comparison with the majority Czech population.
Article in Molecular genetics & genomic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 14 citations in OpenAlex.
- Genetic Determinants of Leisure-Time Physical Activity in the Hungarian General and Roma Populations.International journal of molecular sciences · 2023Article
- The role of mFrontiers in endocrinology · 2023Review
- Effects of selected inherited factors on susceptibility to SARS-CoV-2 infection and COVID-19 progression.Physiological research · 2021Review
- CVD Risk Factors in the Ukrainian Roma and Meta-Analysis of Their Prevalence in Roma Populations Worldwide.Journal of personalized medicine · 2021Article
- Genetics of Cardiovascular Disease: How Far Are We from Personalized CVD Risk Prediction and Management?International journal of molecular sciences · 2021Review
- Increased prevalence of the CVD-associated ANRIL allele in the Roma/Gypsy population in comparison with the majority Czech population.Genetics and molecular biology · 2021Article
- Different prevalence of T2DM risk alleles in Roma population in comparison with the majority Czech population.Molecular genetics & genomic medicine · 2020Article
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5 authors at 2 institutions in 1 country.
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Abstract
backgroundThe Czech governmental study suggests up to a 25% higher prevalence of type 2 diabetes mellitus (T2DM) in the Roma population than within the majority population. It is not known whether and to what extent these differences have a genetic background.
methodsTo analyze whether the frequencies of the alleles/genotypes of the FTO, TCF7L2, CDKN2A/2B, MAEA, TLE4, IGF2BP2, ARAP1, and KCNJ11 genes differ between the two major ethnic groups in the Czech Republic, we examined them in DNA samples from 302 Roma individuals and 298 Czech individuals.
resultsCompared to the majority population, Roma are more likely to carry risk alleles in the FTO (26% vs. 16% GG homozygotes, p < .01), IGF2BP2 (22% vs. 10% TT homozygotes, p < .0001), ARAP1 (98% vs. 95% of A allele carriers, p < .005), and CDKN2A/2B (81% vs. 66% of TT homozygotes, p < .001) genes; however, less frequently they are carriers of the TCF7L2 risk allele (34% vs. 48% of the T allele p < .0005). Finally, we found significant accumulation of T2DM-associated alleles between the Roma population in comparison with the majority population (25.4% vs. 15.2% of the carriers of at least 12 risk alleles; p < .0001).
conclusionThe increased prevalence of T2DM in the Roma population may have a background in different frequencies of the risk alleles of genes associated with T2DM development.
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