Evidence map›Paper›PMID 32578859›Full record

ArticleEuropean heart journal2020

New-onset atrial fibrillation: incidence, characteristics, and related events following a national COVID-19 lockdown of 5.6 million people.

Anders Holt, Gunnar H Gislason, Morten Schou, Bochra Zareini, Tor Biering-Sørensen, Matthew Phelps, Kristian Kragholm, Charlotte Andersson, Emil L Fosbøl, Morten Lock Hansen and 4 more

Abstract readMulticenter Study
In one paragraph

Article in European heart journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Review
  8. The impact of social distancing on mental health during the COVID-19 pandemic: a nationwide study of 4.6 million Danish adults.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Article
  9. Article
  10. COVID-19 and stroke in women: impact on clinical, psychosocial and research aspects.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Anders HoltDepartment of Cardiology, Herlev and Gentofte University Hospital, Copenhagen, Denmark.
Gunnar H GislasonDepartment of Cardiology, Herlev and Gentofte University Hospital, Copenhagen, Denmark.
Morten SchouDepartment of Cardiology, Herlev and Gentofte University Hospital, Copenhagen, Denmark.
Bochra ZareiniDepartment of Cardiology, Herlev and Gentofte University Hospital, Copenhagen, Denmark.
Tor Biering-SørensenDepartment of Cardiology, Herlev and Gentofte University Hospital, Copenhagen, Denmark.
Matthew PhelpsDanish Heart Foundation, Copenhagen, Denmark.
Kristian KragholmDepartment of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
Charlotte AnderssonDepartment of Medicine, Section of Cardiovascular Medicine, Boston Medical Center, Boston University, MA, USA.
Emil L FosbølDepartment of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Morten Lock HansenDepartment of Cardiology, Herlev and Gentofte University Hospital, Copenhagen, Denmark.
Thomas A GerdsDanish Heart Foundation, Copenhagen, Denmark.
Lars KøberDepartment of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Christian Torp-PedersenDepartments of Clinical investigation and Cardiology, Nordsjællands Hospital, Hillerød, Denmark.
Morten LambertsDepartment of Cardiology, Herlev and Gentofte University Hospital, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo determine the incidence, patient characteristics, and related events associated with new-onset atrial fibrillation (AF) during a national COVID-19 lockdown. METHODS AND

resultsUsing nationwide Danish registries, we included all patients, aged 18-90 years, receiving a new-onset AF diagnosis during the first 3 months of 2019 and 2020. The main comparison was between patients diagnosed during lockdown (12 March 12-1 April 2020) and patients diagnosed in the corresponding period 1 year previously. We found a lower incidence of new-onset AF during the 3 weeks of lockdown compared with the corresponding weeks in 2019 [incidence rate ratios with 95% confidence intervals (CIs) for the 3 weeks: 0.66 (0.56-0.78), 0.53 (0.45-0.64), and 0.41 (0.34-0.50)]. There was a 47% drop in total numbers (562 vs. 1053). Patients diagnosed during lockdown were younger and with a lower CHA2DS2-VASc score, while history of cancer, heart failure, and vascular disease were more prevalent. During lockdown, 30 (5.3%) patients with new-onset AF suffered an ischaemic stroke and 15 (2.7%) died, compared with 45 (4.3%) and 14 (1.3%) patients during the corresponding 2019 period, respectively. The adjusted odds ratio of a related event (ischaemic stroke or all-cause death) during lock-down compared with the corresponding weeks was 1.41 (95% CI 0.93-2.12).

conclusionsFollowing a national lockdown in Denmark, a 47% drop in registered new-onset AF cases was observed. In the event of prolonged or subsequent lockdowns, the risk of undiagnosed AF patients developing complications could potentially translate into poorer outcomes in patients with AF during the COVID-19 pandemic.

Indexed as

BetacoronavirusPandemicsRegistriesAdolescentAdultAgedAged, 80 and overAtrial FibrillationBrain IschemiaCoronavirus InfectionsCOVID-19DenmarkFemaleHumansIncidenceMaleAtrial fibrillationCollateral damageCOVID-19 pandemicNational lockdown

Identifiers

PMID32578859
PMCPMC7337750

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.