ArticleSao Paulo medical journal = Revista paulista de medicina2020
Risk factors associated with drug therapy among elderly people with Alzheimer's disease: a cross-sectional study.
Article in Sao Paulo medical journal = Revista paulista de medicina, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global prevalence of polypharmacy and potentially inappropriate medication in older patients with dementia: a systematic review and meta-analysis.Frontiers in pharmacology · 2023Pooled it
- Falls and Sleep Disorders in Spanish Alzheimer's Disease in Nursing Homes: An Observational Study.Healthcare (Basel, Switzerland) · 2023Article
- Hospitalizations of older people in an emergency department related to potential medication-induced hyperactive delirium: a cross-sectional study.International journal of clinical pharmacy · 2022Article
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4 authors.
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Abstract
backgroundImproving knowledge and establishing strategies and policies for better patient safety are worldwide priorities.
objectiveTo evaluate drug safety among elderly people with Alzheimer's disease (AD). DESIGN AND
settingCross-sectional study among elderly people within the National AD Assistance Protocol (PCDTDA/MS) who were living in the municipality of Araraquara, Brazil, in 2017.
methodsThrough interviews conducted with relatives/caregivers of elderly people with diagnoses of AD, the following variables were evaluated: comorbidities, drug therapy used, use of potentially inappropriate medications for the elderly (PIMs), presence of potentially inappropriate interactions (PIIs) and medication regimen complexity index. Factors associated with AD severity were also evaluated. Multivariate and simple logistic regressions were applied.
results143 elderly people enrolled in PCDTDA/MS were analyzed. The majority were women (67.1%); assisted only through the public healthcare system (75.5%); polymedicated (57.4%); using at least one PIM (63.6%); presenting at least one PII (63.6%); and under drug therapy of low to medium complexity (92.2%). No semi-annual monitoring of the effectiveness of PCDTDA/MS drugs was identified. The proportion using AD drug therapy at daily doses differing from those recommended by the World Health Organization was 75.6%. However, these doses were not associated with drug risk.
conclusionThe data from this study raise the hypothesis that use of polypharmacy might show a correlation with severity of AD. The drug safety risk may be associated with comorbidities of the metabolic syndrome, anxiety and off-label use of PIMs, such as risperidone and quetiapine, and benzodiazepines (i.e. clonazepam and flunitrazepam).
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