SynthesisJournal of the American Heart Association2020
Extracorporeal Life Support in Pregnancy: A Systematic Review.
Synthesis in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Contemporary approaches to extracorporeal membrane oxygenation usage in extended peripartum period over a decade - a systematic review.BMC pregnancy and childbirth · 2026Pooled it
- Advanced resuscitation strategies for cardiac arrest in pregnancy: a systematic review.BMC cardiovascular disorders · 2026Pooled it
- Extracorporeal Life Support in Pregnancy: A Systematic Review.Journal of the American Heart Association · 2020Pooled it
- ECPR in Maternal Cardiac Arrest With Intrauterine Fetal Demise.JACC. Case reports · 2026Article
- Extracorporeal Cardiopulmonary Resuscitation for Periviable Pregnancy With a Fetus In Situ.JACC. Case reports · 2026Article
- Managing pregnancy in women with pre-existing cardiomyopathies: A case series.Case reports in women's health · 2026Article
- Article
- Evidence-based guidelines for the use of extracorporeal membrane oxygenation in Australia and New Zealand using GRADE methodology series part 1: Venovenous extracorporeal membrane oxygenation (VV ECMO) indications and management.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- Cardiopulmonary arrest and cardiopulmonary resuscitation in pregnancy Number 3 - 2026.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2026Article
- Review
- Caring for Two: Management of the Critically Ill Cardiac Patient During Pregnancy.JACC. Advances · 2025Review
- Article
- Venoarterial extracorporeal membrane oxygenation is a feasible option for patients with pregnancy-associated diagnoses who require mechanical circulatory support.Resuscitation plus · 2025Article
- Extracorporeal membrane oxygenation (ECMO) in pediatric congenital heart disease: a comprehensive review.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025Review
- Maternal heart failure: state-of-the-art review.Heart failure reviews · 2025Review
- Clinical approach to respiratory failure in the obstetric patient: a comprehensive clinical review.Proceedings (Baylor University. Medical Center) · 2025Review
- Cardio-obstetrics in the Cardiac Intensive Care Unit: An Introductory Guide.US cardiology · 2025Review
- Challenges during cardiac arrest in pregnancy.Resuscitation plus · 2025Article
- Management of cardiopulmonary bypass in pregnancy: challenges and progress in maternal-fetal protection.Frontiers in cardiovascular medicine · 2025Review
- Maternal sepsis: background, diagnosis and management.BJA education · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Background The use of extracorporeal life support (ECLS) has expanded to include unique populations such as peripartum women. This systematic review aims to (1) quantify the number of cases and indications for ECLS in women during the peripartum period reported in the literature and (2) report maternal and fetal complications and outcomes associated with peripartum ECLS. Methods and Results This review was registered in PROSPERO (CRD42018108142). MEDLINE, Embase, and CINAHL were searched for case reports, case series, and studies reporting cases of ECLS during the peripartum period that reported one or more of the following outcomes: maternal survival, maternal complications, fetal survival, and/or fetal complications. Qualitative assessment of 221 publications evaluated the number of cases, clinical details, and maternal and fetal outcomes of ECLS during the peripartum period. There were 358 women included and 68 reported fetal outcomes in cases where the mother was pregnant at the time of cannulation. The aggregate maternal survival at 30 days was 270 (75.4%) and at 1 year was 266 (74.3%); fetal survival was 44 (64.7%). The most common indications for ECLS overall in pregnancy included acute respiratory distress syndrome 177 (49.4%), cardiac failure 67 (18.7%), and cardiac arrest 57 (15.9%). The most common maternal complications included mild to moderate bleeding 66 (18.4%), severe bleeding requiring surgical intervention 48 (13.4%), and intracranial neurologic morbidity 19 (5.3%). The most commonly reported fetal complications included preterm delivery 33 (48.5%) and neonatal intensive care unit admission 19 (27.9%). Conclusions Reported rates of survival in ECLS in pregnant and postpartum women are high and major complications relatively low.
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Registered trials
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