ArticleCancer medicine2020
Sex differences in solid pseudopapillary neoplasm of the pancreas: A population-based study.
Article in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Management and outcomes of solid pseudopapillary neoplasm of the pancreas: a systematic review.Clinical and experimental medicine · 2025Pooled it
- Large periampullary mass with vascular contact: Diagnostic and surgical decision-making in a solid pseudopapillary neoplasm.Radiology case reports · 2026Article
- Pancreatic solid pseudopapillary neoplasms in male patients exhibit different clinical and imaging features compared with those in female patients.Abdominal radiology (New York) · 2026Article
- Tailored Surgical Treatment and Outcomes in Solid Pseudopapillary Neoplasms of the Pancreas: A Case Series of Five Consecutive Paradigmatic Cases.Diseases (Basel, Switzerland) · 2026Article
- Development and validation of a nomogram for overall survival in pancreatic solid pseudopapillary neoplasm: a population-based study.Scientific reports · 2026Article
- Sex hormone receptor signaling networks drive pancreatic solid-pseudopapillary neoplasm pathogenesis and therapy.Discover oncology · 2025Review
- Solid pseudopapillary neoplasm of the pancreas: A case report.Experimental and therapeutic medicine · 2025Article
- Review
- Diagnostic insights into solid pseudopapillary neoplasms of the pancreas: a decade of experience with pediatric representation.Diagnostic pathology · 2025Article
- Extra-pancreatic solid pseudopapillary neoplasm: a case report of primary testis origin and review of the literature.Frontiers in oncology · 2025Article
- Solid pseudopapillary neoplasm (SPN) of the pancreas: current understanding on its malignant potential and management.Discover oncology · 2024Review
- Solid pseudopapillary neoplasm of the pancreas: a retrospective study of 195 cases.Frontiers in oncology · 2024Article
- Solid pseudopapillary neoplasm of the pancreas with hepatic metastases: problems and strategies.Frontiers in oncology · 2024Review
- Solid pseudopapillary neoplasms of the pancreas in childhood and adolescence-an analysis of the German Registry for Rare Pediatric Tumors (STEP).European journal of pediatrics · 2023Article
- Comprehensive study of clinical features, prognostic factors, and survival in patients with pancreatic solid pseudopapillary neoplasms based on the 2019 WHO classification.Journal of cancer research and clinical oncology · 2023Article
- Complete enucleation of a complicated solid pseudopapillary neoplasm of pancreas: A case report.International journal of surgery case reports · 2023Article
- Perioperative safety and prognosis following parenchyma-preserving surgery for solid pseudopapillary neoplasm of the pancreas.World journal of surgical oncology · 2023Article
- Reporting a Case of Solid Pseudopapillary Neoplasm of the Pancreas in a 44-Year-Old Woman with Parallel Analysis of Literature.Case reports in oncological medicine · 2023Article
- Solid Pseudopapillary Neoplasm of the Pancreas: Unfolding an Intriguing Condition.GE Portuguese journal of gastroenterology · 2022Review
- Cytological Diagnosis of Pancreatic Solid-Pseudopapillary Neoplasm: A Single-Institution Community Practice Experience.Diagnostics (Basel, Switzerland) · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSolid pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor. This study aims to examine the clinicopathological features and surgical treatments of SPN and compare the clinical behavior and prognosis between men and women with SPN.
methodsWe collected the population data of patients with SPN diagnosed between 2004 and 2017 from the SEER database. The Kaplan-Meier method was used to analyze overall survival (OS) and disease-specific survival (DSS), and log-rank tests were used to evaluate the differences between subgroups. Univariate and multivariate Cox regression analyses were performed to screen out prognostic risk factors of SPN.
resultsA total of 378 patients with SPN were included, with 246 (65.1%) female patients. 1-, 3-, and 5-year overall survival rates were 98.9%, 95.7%, and 93.7%, respectively. Survival analysis revealed that regardless of stage, patients with SPN who underwent surgical interventions still had a significantly better prognosis than those without surgical interventions (P < .001). The patients with lymphatic dissection had a significantly better prognosis than those without lymphatic dissection (P < .001). Moreover, compared with female patients, male patients had significantly poorer OS and DSS (P < .001). Female SPN showed a bimodal age-frequency distribution with early-onset incidence at 28 years and late-onset peak incidence at 62 years, while male SPN presented a unimodal distribution with peak incidence at approximately age 64 years. In female patients, the tumor size in premenopausal females (<65 years old) was significantly larger than that in postmenopausal females (≥65 years old) (P < .001). Clinicopathological characteristic profiles were different not only between male SPN and premenopausal female SPN but also between premenopausal and postmenopausal female SPN.
conclusionSPN presents indolent behavior and predominantly occurs in young women. Regardless of stage, surgical intervention is recommended. Moreover, our study is the first large enough study to demonstrate sex-related discrepancies in SPN. Thus, different treatment strategies should be designed for patients of different sexes at different ages and hormone therapy is a promising approach for SPN.
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