ArticleNeurourology and urodynamics2020
The Multidisciplinary Approach to The Study of Chronic Pelvic Pain (MAPP) Research Network*: Design and implementation of the Symptom Patterns Study (SPS).
Article in Neurourology and urodynamics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
28 citing papers in PubMed, 30 citations in OpenAlex.
- Concordance between the fast and efficient mixed-effects algorithm (FEMA) and conventional mixed-effects modeling for whole-brain connectivity in longitudinal chronic pain.bioRxiv : the preprint server for biology · 2026Article
- The Unique and Joint Associations of Childhood and Recent Life Stressors on Chronic Pain Symptoms.Journal of clinical medicine · 2026Article
- A Review of NIDDK-Funded Studies of Urological Chronic Pain Conditions.Neurourology and urodynamics · 2026Review
- Urologic chronic pelvic pain syndrome 3-year symptom trajectories: the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Symptom Patterns Study.BJU international · 2026Article
- Psychological and Behavioral Contributors to Lower Urinary Tract Dysfunction: Trauma, Stress, and Neurobiological Pathways.Current bladder dysfunction reports · 2026Review
- Towards precision medicine in clinical trials for the treatment of urologic chronic pelvic pain syndrome: lessons from the MAPP Research Network.Nature reviews. Urology · 2025Review
- Widespread Pain Moderates the Response to Centrally-Acting Therapies in an Observational Cohort of Patients With Urologic Chronic Pelvic Pain Syndrome: A MAPP Research Network Study.Neurourology and urodynamics · 2025Observational
- Urologic Chronic Pelvic Pain Syndrome: A Scoping Review of Syndrome-Specific Instruments.Neurourology and urodynamics · 2025Article
- Article
- Relationship of Sex and Diagnosis With Symptoms and Illness Impact in Urologic Chronic Pelvic Pain; A Mapp Network Analysis.Neurourology and urodynamics · 2025Article
- Functional and Structural Characteristics of the Pelvic Floor in Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS).Journal of pain research · 2025Article
- This pain drives me crazy: Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome.World journal of psychiatry · 2024Article
- Ecological momentary assessment of pelvic pain and urinary urgency variability in urologic chronic pelvic pain syndrome and their association with illness impact and quality of life: Findings from the multidisciplinary approach to the study of chronic pelvic pain symptom patterns study.Neurourology and urodynamics · 2024Article
- Validation of a simple body map to measure widespread pain in urologic chronic pelvic pain syndrome: A MAPP Research Network study.Neurourology and urodynamics · 2024Article
- Early and recent exposure to adversity, TLR-4 stimulated inflammation, and diurnal cortisol in women with interstitial cystitis/bladder pain syndrome: A MAPP research network study.Brain, behavior, and immunity · 2023Article
- Clinically Important Differences for Pain and Urinary Symptoms in Urological Chronic Pelvic Pain Syndrome: A MAPP Network Study.The Journal of urology · 2023Article
- Reproducible Microstructural Changes in the Brain Associated With the Presence and Severity of Urologic Chronic Pelvic Pain Syndrome (UCPPS): A 3-Year Longitudinal Diffusion Tensor Imaging Study From the MAPP Network.The journal of pain · 2023Article
- Associations Between Urological Chronic Pelvic Pain Syndrome Symptom Flares, Illness Impact, and Health Care Seeking Activity: Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Symptom Patterns Study.The Journal of urology · 2023Article
- Long-Term Symptom Trajectories in Urologic Chronic Pelvic Pain Syndrome: A MAPP Research Network Study.Urology · 2022Observational
- Clinical Phenotyping for Pain Mechanisms in Urologic Chronic Pelvic Pain Syndromes: A MAPP Research Network Study.The journal of pain · 2022Article
Corrections and comments
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Authors and funding
23 authors at 14 institutions in 2 countries.
Funding
Abstract
aimsThe Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network initiated a second observational cohort study-the Symptom Patterns Study (SPS)-to further investigate the underlying pathophysiology of Urologic Chronic Pelvic Pain Syndrome (UCPPS) and to discover factors associated with longitudinal symptom changes and responses to treatments.
methodsThis multisite cohort study of males and females with UCPPS features a run-in period of four weekly web-based symptom assessments before a baseline visit, followed by quarterly assessments up to 36 months. Controls were also recruited and assessed at baseline and 6 months. Extensive clinical data assessing urological symptoms, nonurological pain, chronic overlapping pain syndromes, and psychosocial factors were collected. Diverse biospecimens for biomarker and microbiome studies, quantitative sensory testing (QST) data under multiple stimuli, and structural and functional neuroimaging scans were obtained under a standardized protocol.
resultsRecruitment was initiated (July 2015) and completed (February 2019) at six discovery sites. A total of 620 males and females with UCPPS and 73 Controls were enrolled, including 83 UCPPS participants who re-enrolled from the first MAPP Network cohort study (2009-2012). Baseline neuroimaging scans, QST measures, and biospecimens were obtained on 578 UCPPS participants. The longitudinal follow-up of the cohort is ongoing.
conclusionsThis comprehensive characterization of a large UCPPS cohort with extended follow-up greatly expands upon earlier MAPP Network studies and provides unprecedented opportunities to increase our understanding of UCPPS pathophysiology, factors associated with symptom change, clinically relevant patient phenotypes, and novel targets for future interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.