Evidence map›Paper›PMID 32578124›Full record

ArticleNeurocritical care2020

The Curing Coma Campaign: Framing Initial Scientific Challenges-Proceedings of the First Curing Coma Campaign Scientific Advisory Council Meeting.

J Javier Provencio, J Claude Hemphill, Jan Claassen, Brian L Edlow, Raimund Helbok, Paul M Vespa, Michael N Diringer, Len Polizzotto, Lori Shutter, Jose I Suarez and 27 more

Open access · hybridAbstract readConference Proceedings
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurocritical care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 1 synthesis or guideline pooled it, 147 citations in OpenAlex.

  1. Pooled it
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  20. Disorders of Consciousness: Classification and Taxonomy.Physical medicine and rehabilitation clinics of North America · 2024
    Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

37 authors at 20 institutions in 6 countries.

J Javier ProvencioDepartment of Neurology and Neuroscience, University of Virginia, Charlottesville, VA, USA.
J Claude HemphillDepartment of Neurology, Zuckerberg San Francisco General Hospital, University of California, San Francisco, Building 1, Room 101, 1001 Potrero Avenue, San Francisco, CA, 94110, USA. claude.hemphill@ucsf.edu.ORCID http://orcid.org/0000-0003-4019-7525
Jan ClaassenDepartment of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
Brian L EdlowDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Raimund HelbokDepartment of Neurology, Neurocritical Care, Medical University of Innsbruck, Innsbruck, Austria.
Paul M VespaDepartments of Neurology and Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Michael N DiringerDepartment of Neurology, Washington University, Barnes-Jewish Hospital, St Louis, MO, USA.
Len PolizzottoDepartment of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA.
Lori ShutterDepartments of Critical Care Medicine, Neurology, and Neurosurgery, University of Pittsburgh/UPMC Health System, Pittsburgh, PA, USA.
Jose I SuarezDepartments of Anesthesiology and Critical Care Medicine, Neurology and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Robert D StevensDepartments of Anesthesiology and Critical Care Medicine, Neurology and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Daniel F HanleyDivision of Brain Injury Outcomes, Johns Hopkins University, Baltimore, MD, USA.
Yama AkbariDepartments of Neurology, Neurosurgery and the Beckman Laser Institute, University of California-Irvine, Irvine, CA, USA.
Thomas P BleckDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Melanie BolyDepartment of Neurology, University of Wisconsin-Madison, Madison, WI, USA.
Brandon ForemanDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati Gardner Neuroscience Institute, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Joseph T GiacinoDepartment of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, USA.
Jed A HartingsDepartment of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Theresa HumanDepartments of Neurology and Neurosurgery, Washington University, Barnes-Jewish Hospital, St Louis, MO, USA.
Daniel KondziellaDepartment of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Geoffrey S F LingDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Stephan A MayerDepartments of Neurology and Neurosurgery, New York Medical College, Valhalla, NY, USA.
Molly McNettCollege of Nursing, The Ohio State University, Columbus, OH, USA.
David K MenonDivision of Anaesthesia, University of Cambridge, Cambridge, UK.
Geert MeyfroidtDepartment and Laboratory of Intensive Care Medicine, University Hospitals Leuven and KU Leuven, Leuven, Belgium.
Martin M MontiDepartment of Psychology, University of California, Los Angeles, CA, USA.
Soojin ParkDepartment of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
Nader PouratianDepartment of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Louis PuybassetDepartment of Anesthesiology and Critical Care, Sorbonne University, GRC 29, AP-HP, DMU DREAM, Pitié-Salpêtrière Hospital, 75013, Paris, France.
Benjamin RohautDepartment of Neurology, Neuro-ICU, Sorbonne University, Pitié-Salpêtrière Hospital, Paris, France.
Eric S RosenthalDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Nicholas D SchiffDepartments of Neurology, Neuroscience, and Medical Ethics, Weill Cornell Medicine, New York, NY, USA.
Tarek SharsharNeuro-anesthesiology and Intensive Care Medicine, Sainte-Anne Hospital, Paris-Descartes University, Paris, France.
Amy WagnerDepartment of Physical Medicine and Rehabilitation, Department of Neuroscience, Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, USA.
John WhyteMoss Rehabilitation Research Institute, Elkins Park, PA, USA.
DaiWai M OlsonDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern, Dallas, TX, USA.
Neurocritical Care Society Curing Coma Campaign
Johns Hopkins University · USHarvard University · USUniversity of California, Los Angeles · USBarnes-Jewish Hospital · USNewYork–Presbyterian Hospital · USSorbonne Université · FRUniversity of Cincinnati Medical Center · USUniversity of Pittsburgh · USCopenhagen University Hospital · DKCornell University · USInnsbruck Medical University · ATInstitut Pasteur · FRKU Leuven · BEMoss Rehabilitation Hospital · USNew York Medical College · USNorthwestern University · USSan Francisco General Hospital · USThe Ohio State University · USThe University of Texas Southwestern Medical Center · USUniversity of California, Irvine · US

Funding

Institutional Career Development CoreKL2TR001416 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, DEMETRIOU, MICHAEL · 2015 to 2023
$5.6M
Real-Time Prediction of Delayed Cerebral Ischemia after Subarachnoid HemorrhageK23NS105950 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ROSENTHAL, ERIC S. · 2018 to 2022
$1.0M
The Impact of Intracranial Pressure on Cortical Functioning and Cognitive Outcome after Traumatic Brain InjuryK23NS101123 · NINDS · UNIVERSITY OF CINCINNATI · PI FOREMAN, BRANDON · 2017 to 2020
$797k
NCATS NIH HHS KL2 TR001416NINDS NIH HHS K23 NS101123NINDS NIH HHS K23 NS105950
6 · The paper itself

Abstract

Coma and disordered consciousness are common manifestations of acute neurological conditions and are among the most pervasive and challenging aspects of treatment in neurocritical care. Gaps exist in patient assessment, outcome prognostication, and treatment directed specifically at improving consciousness and cognitive recovery. In 2019, the Neurocritical Care Society (NCS) launched the Curing Coma Campaign in order to address the "grand challenge" of improving the management of patients with coma and decreased consciousness. One of the first steps was to bring together a Scientific Advisory Council including coma scientists, neurointensivists, neurorehabilitationists, and implementation experts in order to address the current scientific landscape and begin to develop a framework on how to move forward. This manuscript describes the proceedings of the first Curing Coma Campaign Scientific Advisory Council meeting which occurred in conjunction with the NCS Annual Meeting in October 2019 in Vancouver. Specifically, three major pillars were identified which should be considered: endotyping of coma and disorders of consciousness, biomarkers, and proof-of-concept clinical trials. Each is summarized with regard to current approach, benefits to the patient, family, and clinicians, and next steps. Integration of these three pillars will be essential to the success of the Curing Coma Campaign as will expanding the "curing coma community" to ensure broad participation of clinicians, scientists, and patient advocates with the goal of identifying and implementing treatments to fundamentally improve the outcome of patients.

Indexed as

Critical CareImplementation ScienceNeurological RehabilitationNeurologyAdvisory CommitteesBiomarkersClinical Trials as TopicComaConsciousness DisordersHumansProof of Concept StudyStakeholder ParticipationBiomarkersBiomarkerComaConsciousnessEndotypeRecovery

Identifiers

PMID32578124
PMCPMC7392933
OpenAlexW3037675720

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.