Evidence map›Paper›PMID 32578041›Full record

ReviewNeurotoxicity research2020

Non-coding RNAs in Ischemic Stroke: Roles in the Neuroinflammation and Cell Death.

Meng Lu, Xingang Dong, Zhenqiang Zhang, Weifeng Li, Seyed Esmaeil Khoshnam

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurotoxicity research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Meng LuAcademy of Traditional Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Xingang DongFrist Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, 450008, China.
Zhenqiang ZhangAcademy of Traditional Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Weifeng LiThird Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, 450008, China. 13613829325@163.com.
Seyed Esmaeil KhoshnamPhysiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Esmaeil.khoshnam1392@gmail.com.ORCID http://orcid.org/0000-0002-3834-4242
Henan University of Traditional Chinese Medicine · CNAhvaz Jundishapur University of Medical Sciences · IRFirst Affiliated Hospital of Henan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke is one of the leading causes of death and long-term disability worldwide. As an important class of pervasive genes involved in many pathophysiological processes of ischemic stroke, non-coding RNAs (ncRNAs) have received attention in the past decades. ncRNAs are a class of functional RNAs that regulate gene expression in a post-transcriptional manner, and including microRNAs, long non-coding RNAs, and circular RNAs. Several studies have deciphered that ncRNAs have a key role in the ischemic stroke-induced neuroinflammation and cell death via different molecules and pathways. Thus, ncRNAs show great promise as novel molecular targets in ischemic stroke. In this article, we provide an updated review of the current state of our knowledge about the roles of different types of ncRNAs in neuroinflammation and cell death following ischemic stroke, which may facilitate the translation of ncRNAs research into clinical practice to improve the clinical outcome of stroke therapy.

Indexed as

AnimalsBrain IschemiaCell DeathGene ExpressionHumansRNA, Long NoncodingRNA, UntranslatedStrokeRNA, Long NoncodingRNA, UntranslatedCell deathIschemic strokeNeuroinflammationNon-coding RNAs

Identifiers

PMID32578041
OpenAlexW3037033377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.