Evidence map›Paper›PMID 32578009›Full record

ArticleMolecular neurobiology2020

Molecular Mechanisms for Krüppel-Like Factor 13 Actions in Hippocampal Neurons.

José Ávila-Mendoza, Arasakumar Subramani, Christopher J Sifuentes, Robert J Denver

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

José Ávila-MendozaDepartment of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, MI, 48109, USA.ORCID https://orcid.org/0000-0003-3073-4737
Arasakumar SubramaniDepartment of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, MI, 48109, USA.ORCID https://orcid.org/0000-0002-6563-6689
Christopher J SifuentesDepartment of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, MI, 48109, USA.ORCID https://orcid.org/0000-0001-7574-2015
Robert J DenverDepartment of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, MI, 48109, USA. rdenver@umich.edu.ORCID https://orcid.org/0000-0002-2773-8174
University of Michigan · US

Funding

Consejo Nacional de Ciencia y Tecnología (CONACYT) CVU-267642Division of Integrative Organismal Systems IOS 1456115
6 · The paper itself

Abstract

Krüppel-like factors (KLFs) play key roles in nervous system development and function. Several KLFs are known to promote, and then maintain neural cell differentiation. Our previous work focused on the actions of KLF9 in mouse hippocampal neurons. Here we investigated genomic targets and functions of KLF9's paralog KLF13, with the goal of understanding how these two closely related transcription factors influence hippocampal cell function, proliferation, survival, and regeneration. We engineered the adult mouse hippocampus-derived cell line HT22 to control Klf13 expression with doxycycline. We also generated HT22 Klf13 knock out cells, and we analyzed primary hippocampal cells from wild type and Klf13

Indexed as

AnimalsBase SequenceCell CycleCell Cycle ProteinsCell LineCytoprotectionDoxycyclineGene Expression RegulationGenes, ReporterHippocampusKruppel-Like Transcription FactorsMice, Inbred C57BLNeuronsPromoter Regions, GeneticRepressor ProteinsReproducibility of ResultsCell Cycle ProteinsDoxycyclineKlf13 protein, mouseKlf9 protein, mouseKruppel-Like Transcription FactorsRepressor ProteinsCell cycleCell survivalChromatinHippocampusKrüppel-like factorsTranscription

Identifiers

PMID32578009
OpenAlexW3037396419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.