Evidence map›Paper›PMID 32577993›Full record

ArticleMolecular biology reports2020

The correlation of combined OGG1, CYP1A1 and GSTP1 gene variants and risk of lung cancer of male Iraqi waterpipe tobacco smokers.

Bassam K Kudhair, Noralhuda N Alabid, Karrar S Zayed, Inam J Lafta, Asghar Taheri-Kafrani

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In one paragraph

Article in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. TheArab journal of basic and applied sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Bassam K KudhairDepartment of Laboratory Investigations, Faculty of Science, University of Kufa, 54001, Najaf, Iraq. bassamk.sharuza@uokufa.edu.iq.ORCID http://orcid.org/0000-0002-4493-1718
Noralhuda N AlabidDepartment of Urban Planning, Faculty of Physical Planning, University of Kufa, 54001, Najaf, Iraq.
Karrar S ZayedDepartment of Laboratory Investigations, Faculty of Science, University of Kufa, 54001, Najaf, Iraq.
Inam J LaftaDepartment of Microbiology, College of Veterinary Medicine, University of Baghdad, Baghdad, 10071, Iraq.
Asghar Taheri-KafraniDepartment of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, 81746-73441, Isfahan, Iran.
University of Kufa · IQUniversity of Baghdad · IQUniversity of Isfahan · IR

Funding

University of Kufa BKK00587
6 · The paper itself

Abstract

Genetic polymorphisms of genes whose products are responsible for activities, such as xenobiotic metabolism, mutagen detoxification and DNA-repair, have been predicted to be associated with the risk of developing lung cancer (LC). The association of LC with tobacco smoking has been extensively investigated, but no studies have focused on the Arab ethnicity. Previously, we examined the association between genetic polymorphisms among Phase I and Phase II metabolism genes and the risk of LC. Here, we extend the data by examining the correlation of OGG1 Ser326Cys combined with CYP1A1 (Ile462Val and MspI) and GSTP1 (Ile105Val and Ala103Val) polymorphisms with the risk of LC. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and gene sequencing were carried out for genotyping the OGG1 polymorphisms of 123 LC patients and 129 controls. No significant differences in the frequencies of the OGG1 mutant allele between patients and controls were found. The distributions of heterozygous Ser/Cys or Cys/Cys genotypes of OGG1 were not associated with the risk of LC either according to the histological types of LC or based on waterpipe tobacco (WP) smoking status. In contrast, the combined effect of OGG1 variants with CYP1A1 and GSTP1 variants revealed a significant correlation with the OGG1 Ser326Cys-CYP1A1 MspI variants pairing. This association was significant (p = 0.001) in individuals who carried homozygous or heterozygous variant type genotypes of both genes in a reference with carriers of both wild-type genotypes (wt/wt - wt/wt). The odds ratios were 2.99 (95% CI 1.67-5.36), 2.68 (95% CI 1.08-6.62), and 2.80 (95% CI 1.18-6.69) for those who carried (wt/wt - wt/vt + vt/vt), (wt/vt + vt/vt - wt/wt), and (wt/vt + vt/vt - wt/vt + vt/vt), respectively. The study suggests a limited correlation is present between carrying OGG1 Ser326Cys polymorphism and the risk of developing LC in Arab populations.

Indexed as

Polymorphism, Single NucleotideCytochrome P-450 CYP1A1DNA GlycosylasesGlutathione S-Transferase piHumansIraqLung NeoplasmsMaleMiddle AgedSmokersWater Pipe SmokingCYP1A1 protein, humanCytochrome P-450 CYP1A1DNA GlycosylasesGlutathione S-Transferase piGSTP1 protein, humanoxoguanine glycosylase 1, human8-oxoguanine DNA glycosylaseCYP1A1GSTP1Lung cancerOGG1rs1052133Waterpipe tobacco

Identifiers

PMID32577993
OpenAlexW3036563019

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.