ArticleMetabolomics : Official journal of the Metabolomic Society2020
Metabolic signatures provide novel insights to Picrorhiza kurroa adaptation along the altitude in Himalayan region.
Article in Metabolomics : Official journal of the Metabolomic Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 55 citations in OpenAlex.
- Carbon Gain, Carbon Use, and Persistence: How Elevated CO₂ and Warming Reshape High-Elevation Plants.Plant, cell & environment · 2026Review
- Antibacterial, Antioxidant Potential, and Chemodiversity of Aesculus indica Bark Extracts Along the Garhwal Himalayan Altitudinal Gradient.Chemistry & biodiversity · 2026Article
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- Adaptation of High-Altitude Plants to Harsh Environments: Application of Phenotypic-Variation-Related Methods and Multi-Omics Techniques.International journal of molecular sciences · 2024Review
- Integrated Metabolomic and Transcriptomic Analysis ofMetabolites · 2024Article
- Spatio-Temporal Variations of Volatile Metabolites as an Eco-Physiological Response of a Native Species in the Tropical Forest.Plants (Basel, Switzerland) · 2024Article
- Metabolomics analysis reveals the metabolite profiles of Rheum tanguticum grown under different altitudinal gradients.BMC plant biology · 2024Article
- Altitudinal Variation on Metabolites, Elements, and Antioxidant Activities of Medicinal PlantMetabolites · 2023Article
- Single and interactive effects of variables associated with climate change on wheat metabolome.Frontiers in plant science · 2022Article
- In-depth assembly of organ and development dissected Picrorhiza kurroa proteome map using mass spectrometry.BMC plant biology · 2021Article
- Altitudinal Variation of Metabolites, Mineral Elements and Antioxidant Activities ofMolecules (Basel, Switzerland) · 2021Article
- Soil and Leaf Nutrients Drivers on the Chemical Composition of the Essential Oil ofMolecules (Basel, Switzerland) · 2021Article
- Integrated Metabolomic and Transcriptomic Analysis of the Flavonoid Accumulation in the Leaves ofFrontiers in plant science · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionAlong the altitude, environmental conditions vary significantly that might influence plant performance and distribution. Adaptation to these changing conditions is a complex biological process that involves reprogramming of genes, proteins and metabolites. The metabolic response of medicinal plants along the altitude has been less explored yet.
objectivesIn the present study, we investigated the adaptation strategies of Picrorhiza kurroa Royle ex Benth. along the altitude in organ specific manner using metabolomic approach.
methodsPicrorhiza kurroa plants at flowering stage were randomly sampled from three altitudes viz. 3400, 3800 and 4100 masl in the Himalayan region. Leaf, root and rhizome were used for LC-MS based non-targeted metabolite profiling and targeted analysis of sugars, amino acids, picrosides and their corresponding phenolic acids.
resultsA total of 220, primary and secondary metabolites (SMs) were identified (p < 0.05) representing an extensive inventory of metabolites and their spatial distribution in P. kurroa. Differential accumulation of metabolites suggests source-sink carbon partitioning, occurrence of partial TCA cycle, ascorbate metabolism, purine catabolism and salvage route, pyrimidine synthesis, lipid alteration besides gibberellins and cytokinin inhibition might be an adaptive strategy to alpine environmental stress along the altitude. Further, marked differences of organ and altitude specific SMs reflect alteration in secondary metabolic pathways. Significant accumulation of picrosides suggests their probable role in P. kurroa adaptation.
conclusionThis study provides a platform that would be useful in deciphering the role of metabolites considered to be involved in plant adaptation.
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