ArticleJournal of the National Cancer Institute2021
Multiple Primary Melanoma Incidence Trends Over Five Decades: A Nationwide Population-Based Study.
Article in Journal of the National Cancer Institute, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Distinguish the Value of the Benign Nevus and Melanomas Using Machine Learning: A Meta-Analysis and Systematic Review.Mediators of inflammation · 2022Pooled it
- Characteristics and overall survival in patients with T1 melanoma: A nationwide matched cohort study.International journal of cancer · 2026Article
- Survival impact of second primary cutaneous and non-cutaneous melanoma in melanoma survivors.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026Article
- Impact of Teledermoscopy on Melanoma Diagnosis and Triage Efficiency in Northern Sweden.Acta dermato-venereologica · 2026Observational
- Burden of malignant melanoma among the elderly population in East Asia from 1990 to 2023 and machine learning projection to 2040.PloS one · 2026Article
- Multiple Melanomas on Speckled Lentiginous Nevus: A Systematic Review and a Case Report.Journal of clinical medicine · 2025Review
- Multiple Primary Melanomas: Clinical and Genetic Insights for Risk-Stratified Surveillance in a Tertiary Center.Journal of personalized medicine · 2025Article
- Analysis and comparison of the trends in burden of malignant cutaneous melanoma in East Asian countries and regions and worldwide from 1991 to 2021.Frontiers in public health · 2025Article
- Article
- Epidemiology, Pattern, and Survival of Multiple Primary Malignant Neoplasms in Southeast Iran: Results of Kerman Population-Based Cancer Registry 2014-2020.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Three-Dimensional Total Body Photography, Digital Dermoscopy, and in vivo Reflectance Confocal Microscopy for Follow-Up Assessments of High-Risk Patients for Melanoma: A Prospective, Controlled Study.Dermatology (Basel, Switzerland) · 2024Article
- The Role of Hedgehog Signaling in the Melanoma Tumor Bone Microenvironment.International journal of molecular sciences · 2023Article
- Article
- Multiple Primary Melanomas: Retrospective Review in a Tertiary Care Hospital.Journal of clinical medicine · 2022Article
- Malignant melanoma: evolving practice management in an era of increasingly effective systemic therapies.Current problems in surgery · 2022Review
- Season of birth is associated with multiple sclerosis and disease severity.Multiple sclerosis journal - experimental, translational and clinical · 2021Article
- Genotypic vs Phenotypic Risk Assessment for Melanoma.Journal of the National Cancer Institute · 2021Article
- Surveillance After a Previous Cutaneous Melanoma Diagnosis: A Scoping Review of Melanoma Follow-Up Guidelines.Journal of cutaneous medicine and surgeryArticle
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOver the past decades, many regions have experienced a steady increase in the incidence of cutaneous melanoma. Here, we report on incidence trends for subsequent primary melanoma.
methodsIn this nationwide population-based study, patients diagnosed with a first primary cutaneous melanoma reported to the Swedish Cancer Registry were followed for up to 10 years for a diagnosis of subsequent primary melanoma. Patients were grouped with patients diagnosed with first melanoma in the same decade (1960s, 1970s, 1980s, 1990s, and 2000s, respectively). Frequencies, incidence rates (IRs), standardized incidence ratios (SIRs), and 95% confidence intervals (CIs) for second melanomas were calculated. All tests of statistical significance were 2-sided.
resultsOf patients with melanoma, 54 884 were included and 2469 were diagnosed, within 10 years, with subsequent melanomas. Over the 5 decades, there was a statistically significant steady increase in the frequency, IR, and SIR for second primary melanoma. For example, in the 1960s cohort, less than 1% (IR = 1.0, 95% CI = 0.5 to 1.7, and IR = 1.1, 95% CI = 0.5 to 1.9 per 1000 person-years in women and men, respectively) had second primary melanoma, and this rose to 6.4% (IR = 7.5, 95% CI = 6.8 to 8.3, per 1000 person-years) in the women and 7.9% (IR = 10.3, 95% CI = 9.3 to 11.2, per 1000 person-years) in the men in the 2000s cohort. This rise was seen independent of age, sex, invasiveness, or site of the melanoma. Further, in patients diagnosed with a second melanoma, the frequency of those having more than 2 melanomas increased statistically significantly and was 0.0% in the 1960s and rose to 18.0% in the 2000s (P < .001).
conclusionsThis is the first study to evaluate and report on a rising trend for subsequent primary melanoma. Additional primary melanomas worsen the patients' survival, and precautions are needed to turn this steep upgoing trend.
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