Evidence map›Paper›PMID 32577666›Full record

ArticlemedRxiv : the preprint server for health sciences2020

Long-term SARS-CoV-2 RNA Shedding and its Temporal Association to IgG Seropositivity.

Vineet Agarwal, A J Venkatakrishnan, Arjun Puranik, Christian Kirkup, Agustin Lopez-Marquez, Douglas W Challener, John C O'Horo, Matthew J Binnicker, Walter K Kremers, William A Faubion and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Vineet Agarwalnference, inc., One Main Street, Suite 400, East Arcade, Cambridge, MA 02142, USA.
A J Venkatakrishnannference, inc., One Main Street, Suite 400, East Arcade, Cambridge, MA 02142, USA.
Arjun Puraniknference, inc., One Main Street, Suite 400, East Arcade, Cambridge, MA 02142, USA.
Christian Kirkupnference, inc., One Main Street, Suite 400, East Arcade, Cambridge, MA 02142, USA.
Agustin Lopez-Marqueznference, inc., One Main Street, Suite 400, East Arcade, Cambridge, MA 02142, USA.
Douglas W ChallenerMayo Clinic, Rochester MN, USA.
John C O'HoroMayo Clinic, Rochester MN, USA.
Matthew J BinnickerMayo Clinic, Rochester MN, USA.
Walter K KremersMayo Clinic, Rochester MN, USA.
William A FaubionMayo Clinic, Rochester MN, USA.
Andrew D BadleyMayo Clinic, Rochester MN, USA.
Amy W WilliamsMayo Clinic, Rochester MN, USA.
Gregory J GoresMayo Clinic, Rochester MN, USA.
John D HalamkaMayo Clinic, Rochester MN, USA.
William G MoriceMayo Clinic, Rochester MN, USA.
Venky Soundararajannference, inc., One Main Street, Suite 400, East Arcade, Cambridge, MA 02142, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Analysis of 851 COVID-19 patients with a SARS-CoV-2-positive PCR at follow-up shows 99 patients remained SARS-CoV-2-positive after four weeks from initial diagnosis. Surprisingly, a majority of these long-term viral RNA shedders were not hospitalized (61 of 99), with variable PCR Crossing point values over the month post diagnosis. For the 851-patient cohort, the mean lower bound of viral RNA shedding was 17.3 days (SD: 7.8), and the mean upper bound of viral RNA shedding from 668 patients transitioning to confirmed PCR-negative status was 22.7 days (SD: 11.8). Among 104 patients with an IgG test result, 90 patients were seropositive to date, with mean upper bound of time to seropositivity from initial diagnosis being 37.8 days (95%CI: 34.3-41.3). Juxtaposing IgG/PCR tests revealed that 14 of 90 patients are non-hospitalized and seropositive yet shed viral RNA. This study emphasizes the need for monitoring viral loads and neutralizing antibody titers in long-term shedders.

Identifiers

PMID32577666
PMCPMC7302207

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.