Evidence map›Paper›PMID 32577662›Full record

ArticlebioRxiv : the preprint server for biology2020

Relationship between Anti-Spike Protein Antibody Titers and SARS-CoV-2

Eric Salazar, Suresh V Kuchipudi, Paul A Christensen, Todd N Eagar, Xin Yi, Picheng Zhao, Zhicheng Jin, S Wesley Long, Randall J Olsen, Jian Chen and 24 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

34 authors at 6 institutions in 1 country.

Eric SalazarDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas.
Suresh V KuchipudiPenn State Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pennsylvania.
Paul A ChristensenDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas.
Todd N EagarDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas.
Xin YiDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas.
Picheng ZhaoDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas.
Zhicheng JinDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas.
S Wesley LongDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas.
Randall J OlsenDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas.
Jian ChenDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas.
Brian CastilloDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas.
Christopher LevequeDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas.
Dalton M TowersDepartment of Molecular Biosciences, University of Texas at Austin.
Jason LavinderDepartment of Molecular Biosciences, University of Texas at Austin.
Jimmy D GolliharCCDC Army Research Laboratory-South, University of Texas, Austin, Texas.
Jose CardonaCCDC Army Research Laboratory-South, University of Texas, Austin, Texas.
Gregory C IppolitoDepartment of Molecular Biosciences, University of Texas at Austin.
Ruth H NisslyPenn State Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pennsylvania.
Ian M BirdPenn State Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pennsylvania.
Denver GreenawaltPenn State Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pennsylvania.
Randall M RossiHuck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania.
Abinhay GontuPenn State Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pennsylvania.
Sreenidhi SrinivasanDepartment of Animal Science, Pennsylvania State University, University Park, Pennsylvania.
Indira B PoojaryDepartment of Animal Science, Pennsylvania State University, University Park, Pennsylvania.
Isabella M CattadoriCenter for Infectious Disease Dynamics, The Pennsylvania State University, University Park, Pennsylvania.
Peter J HudsonCenter for Infectious Disease Dynamics, The Pennsylvania State University, University Park, Pennsylvania.
Nicole JoselynUSAMRIID (United States Army Medical Research Institute of Infectious Diseases), Frederick, Maryland.
Laura PrugarUSAMRIID (United States Army Medical Research Institute of Infectious Diseases), Frederick, Maryland.
Kathleen HuieUSAMRIID (United States Army Medical Research Institute of Infectious Diseases), Frederick, Maryland.
Andrew HerbertUSAMRIID (United States Army Medical Research Institute of Infectious Diseases), Frederick, Maryland.
David W BernardDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas.
John DyeUSAMRIID (United States Army Medical Research Institute of Infectious Diseases), Frederick, Maryland.
Vivek KapurCenter for Infectious Disease Dynamics, The Pennsylvania State University, University Park, Pennsylvania.
James M MusserDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas.
Pennsylvania State University · USCornell University · USUnited States Army Medical Research Institute of Infectious Diseases · USHouston Methodist · USMethodist Hospital · USThe University of Texas at Austin · US

Funding

Collaborative Influenza Vaccine Innovation Centers (CIVICs): Component A: Vaccine Center75N93019C00050 · NIAID · DUKE UNIVERSITY · PI MOODY, TONY · 2019 to 2025
$69.1M
Determinants of Streptococcus pyogenes virulence in the primate oropharynx: A genome-wide analysisR21AI139369 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI MUSSER, JAMES MALLORY · 2019 to 2020
$444k
Determinants of Streptococcus pyogenes fitness in the female primate genital tract: A genome-wide analysisR21AI146771 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI MUSSER, JAMES MALLORY · 2019 to 2020
$444k
NIAID NIH HHS 75N93019C00050NIAID NIH HHS R21 AI139369NIAID NIH HHS R21 AI146771
6 · The paper itself

Abstract

Newly emerged pathogens such as SARS-CoV-2 highlight the urgent need for assays that detect levels of neutralizing antibodies that may be protective. We studied the relationship between anti-spike ectodomain (ECD) and anti-receptor binding domain (RBD) IgG titers, and SARS-CoV-2 virus neutralization (VN) titers generated by two different

Identifiers

PMID32577662
PMCPMC7302218
OpenAlexW3034521025

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.