Evidence map›Paper›PMID 32577516›Full record

ArticleScience advances2020

Acoustic streaming vortices enable contactless, digital control of droplets.

Peiran Zhang, Chuyi Chen, Xingyu Su, John Mai, Yuyang Gu, Zhenhua Tian, Haodong Zhu, Zhanwei Zhong, Hai Fu, Shujie Yang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 68 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Lab on an end: Micromanipulation using the acoustohydrodynamic pillar array as an end effector.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Sound-controlled fluidic processor.Science advances · 2025
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Capillary wave tweezer.Scientific reports · 2024
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Peiran ZhangDepartment of Mechanical Engineering and Materials Science, Duke University, NC 27708, USA.ORCID 0000-0002-3873-9949
Chuyi ChenDepartment of Mechanical Engineering and Materials Science, Duke University, NC 27708, USA.ORCID 0000-0001-5733-4261
Xingyu SuDepartment of Mechanical Engineering and Materials Science, Duke University, NC 27708, USA.ORCID 0000-0001-9764-0968
John MaiAlfred E. Mann Institute for Biomedical Engineering, University of Southern California, Los Angeles, CA 90007, USA.ORCID 0000-0001-8001-9120
Yuyang GuDepartment of Mechanical Engineering and Materials Science, Duke University, NC 27708, USA.ORCID 0000-0002-6545-2521
Zhenhua TianDepartment of Mechanical Engineering and Materials Science, Duke University, NC 27708, USA.ORCID 0000-0002-1903-5604
Haodong ZhuDepartment of Mechanical Engineering and Materials Science, Duke University, NC 27708, USA.ORCID 0000-0002-8661-2504
Zhanwei ZhongDepartment of Electrical and Computer Engineering, Duke University, NC 27708, USA.ORCID 0000-0002-0946-574X
Hai FuDepartment of Mechanical Engineering and Materials Science, Duke University, NC 27708, USA.ORCID 0000-0002-6322-3186
Shujie YangDepartment of Mechanical Engineering and Materials Science, Duke University, NC 27708, USA.ORCID 0000-0003-2626-3397
Krishnendu ChakrabartyDepartment of Electrical and Computer Engineering, Duke University, NC 27708, USA.
Tony Jun HuangDepartment of Mechanical Engineering and Materials Science, Duke University, NC 27708, USA.ORCID 0000-0003-1205-3313
Duke University · USUniversity of Southern California · US

Funding

Extracellular vesicles and their ncRNA cargo as markers of trophoblast injuryR01HD086325 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI SADOVSKY, YOEL · 2015 to 2019
$3.6M
Enabling Efficient, Fast, Biocompatible Exosome Separation via AcoustofluidicsR01GM132603 · NIGMS · DUKE UNIVERSITY · PI HUANG, TONY JUN · 2019 to 2022
$1.7M
Determining treatment sensitivity in B cell lymphoma by novel microfluidics-based NK cell immunogenicity platformR33CA223908 · NCI · NORTHEASTERN UNIVERSITY · PI EVENS, ANDREW M, HUANG, TONY JUN · 2018 to 2020
$1.2M
An integrated acoustofluidic droplet-sorting platform for classification of lymphocyte activity and functional phenotyping at single cell levelR01GM127714 · NIGMS · NORTHEASTERN UNIVERSITY · PI KONRY, TANIA TALI · 2018 to 2021
$1.2M
Acoustofluidic Separation (AFS), Purification and Raman Spectral Fingerprinting of Single EVs: From Cell of Origin to Target Cell and BiofluidsUG3TR002978 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AN, JI YEONG, GALL, KENNETH A · 2019 to 2020
$823k
NICHD NIH HHS R01 HD086325NIGMS NIH HHS R01 GM127714NIGMS NIH HHS R01 GM132603
6 · The paper itself

Abstract

Advances in lab-on-a-chip technologies are driven by the pursuit of programmable microscale bioreactors or fluidic processors that mimic electronic functionality, scalability, and convenience. However, few fluidic mechanisms allow for basic logic operations on rewritable fluidic paths due to cross-contamination, which leads to random interference between "fluidic bits" or droplets. Here, we introduce a mechanism that allows for contact-free gating of individual droplets based on the scalable features of acoustic streaming vortices (ASVs). By shifting the hydrodynamic equilibrium positions inside interconnected ASVs with multitonal electrical signals, different functions such as controlling the routing and gating of droplets on rewritable fluidic paths are demonstrated with minimal biochemical cross-contamination. Electrical control of this ASV-based mechanism allows for unidirectional routing and active gating behaviors, which can potentially be scaled to functional fluidic processors that can regulate the flow of droplets in a manner similar to the current in transistor arrays.

Identifiers

PMID32577516
PMCPMC7286667
OpenAlexW3034847089

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.