Evidence map›Paper›PMID 32576966›Full record

ArticleMolecular psychiatry2021

Highly variable suicidal ideation: a phenotypic marker for stress induced suicide risk.

Maria A Oquendo, Hanga C Galfalvy, Tse-Hwei Choo, Raksha Kandlur, Ainsley K Burke, M Elizabeth Sublette, Jeffrey M Miller, J John Mann, Barbara H Stanley

Registry-linked trialAbstract read
In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04775160 (Smartphone-based Ecological Momentary Intervention for Secondary Prevention of Suicidal Thoughts and Behavior), which is not on this map. Cited by 41 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04775160 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Smartphone-based Ecological Momentary Intervention for Secondary Prevention of Suicidal Thoughts and Behavior: a Randomised Clinical Trial

TypeinterventionalSponsorInstituto de Investigación Sanitaria de la Fundación Jiménez DíazRan2022 to 2025Enrolled220ConditionsSuicideArmsSmartSafe
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  4. Pooled it
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  9. Observational
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  17. Let's Move Towards Precision Suicidology.Current psychiatry reports · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maria A OquendoUniversity of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA. moquendo@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-7901-5082
Hanga C GalfalvyColumbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.ORCID http://orcid.org/0000-0001-7156-6106
Tse-Hwei ChooColumbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Raksha KandlurNew York State Psychiatric Institute, New York, NY, USA.
Ainsley K BurkeColumbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
M Elizabeth SubletteColumbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Jeffrey M MillerColumbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
J John MannColumbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Barbara H StanleyColumbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.

Funding

Suicidal Behavior: Aggression Subtypes, Childhood Adversity and Stress ResponseP50MH090964 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MANN, JOSEPH JOHN · 2013 to 2022
$23.6M
Neurobiological Underpinnings of Two Suicidal SubtypesR01MH109326 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MANN, JOSEPH JOHN, OQUENDO, MARIA A · 2016 to 2020
$2.4M
NIMH NIH HHS P50 MH090964NIMH NIH HHS R01 MH109326
6 · The paper itself

Abstract

Suicidal behavior (SB) can be impulsive or methodical; violent or not; follow a stressor or no obvious precipitant. This study tested whether childhood trauma, affective lability, and aggressive and impulsive traits predicted greater SI variability. We also assessed whether affective lability, aggressive or impulsive traits explain childhood trauma's effects on SI variability and whether those with highly variable SI respond to stressful events with increases in SI. Finally, we assessed variable SI's trajectory over 2 years. Depressed participants (n = 51) had ecological momentary assessments (EMA) over 7 days at baseline, 3, 6, 12, 18, and 24 months. SI variability was assessed using the square Root of the Mean Square of Successive Deviations. Mixed Effects Models were fit as appropriate. Childhood trauma was associated with subsequent aggression. Physical abuse predicted both aggression and affective lability as well as SI variability, but not impulsivity. In two-predictor models, physical abuse's effect on SI variability was no longer significant, when controlling for the effect of higher aggression and impulsivity. Those with high SI variability exhibited greater increases in SI after stressors compared with those with less variability. We did not find that SI variability changed over time, suggesting it might be trait-like, at least over 2 years. Variable SI predisposes to marked SI increases after stressful events and may be a trait increasing risk for impulsive SB, at least over 2 years.

Indexed as

Suicidal IdeationSuicideAggressionBiomarkersHumansImpulsive BehaviorRisk FactorsSuicide, AttemptedBiomarkers

Identifiers

PMID32576966
PMCPMC7755748

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.