ArticleScientific reports2020
Lipid profile of Trichinella papuae muscle-stage larvae.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Metabolomics and lipidomics studies of parasitic helminths: molecular diversity and identification levels achieved by using different characterisation tools.Metabolomics : Official journal of the Metabolomic Society · 2023Pooled it
- Discovery of novel repurposed anthelminthics againstCurrent research in parasitology & vector-borne diseases · 2026Article
- Techniques, Databases and Software Used for Studying Polar Metabolites and Lipids of Gastrointestinal Parasites.Animals : an open access journal from MDPI · 2024Review
- Anthelmintic efficacy evaluation and mechanism of N-methylbenzo[d]oxazol-2-amine.Scientific reports · 2023Article
- Impact of atorvastatin and mesenchymal stem cells combined with ivermectin on murine trichinellosis.Parasitology research · 2023Article
- Programmed cell death pathways as targets for developing antifilarial drugs: Lessons from the recent findings.Journal of cellular and molecular medicine · 2023Review
- Untargeted serum metabolomics analysis of Trichinella spiralis-infected mouse.PLoS neglected tropical diseases · 2023Article
- Metabolite profiling ofFrontiers in cellular and infection microbiology · 2023Article
- Immunomodulatory and biological properties of helminth-derived small molecules: Potential applications in diagnostics and therapeutics.Frontiers in parasitology · 2022Review
- Identification and profiling of Trichinella spiralis circulating antigens and proteins in sera of mice with trichinellosis.PloS one · 2022Article
- Helminth lipidomics: Technical aspects and future prospects.Current research in parasitology & vector-borne diseases · 2021Review
- Quantitative lipidomic analysis of Ascaris suum.PLoS neglected tropical diseases · 2020Article
- Metabolomes and Lipidomes of the Infective Stages of the Gastrointestinal nematodes,Metabolites · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Outbreaks of trichinellosis caused by Trichinella papuae have been reported in South-East Asia. Mebendazole and thiabendazole are the treatments of choice for trichinellosis; however, both drugs result in significant side effects and are less effective for muscle-stage larvae (L1). An alternative therapeutic agent is needed to improve treatment. Information on lipid composition and metabolic pathways may bridge gaps in our knowledge and lead to new antiparasitics. The T. papuae L1 lipidome was analysed using a mass spectrometry-based approach, and 403 lipid components were identified. Eight lipid classes were found and glycerophospholipids were dominant, corresponding to 63% of total lipids, of which the glycerolipid DG (20:1[11Z]/22:4[7Z,10Z,13Z,16Z]/0:0) (iso2) was the most abundant. Overall, 57% of T. papuae lipids were absent in humans; therefore, lipid metabolism may be dissimilar in the two species. Proteins involved T. papuae lipid metabolism were explored using bioinformatics. We found that 4-hydroxybutyrate coenzyme A transferase, uncharacterized protein (A0A0V1MCB5) and ML-domain-containing protein are not present in humans. T. papuae glycerophospholipid metabolic and phosphatidylinositol dephosphorylation processes contain several proteins that are dissimilar to those in humans. These findings provide insights into T. papuae lipid composition and metabolism, which may facilitate the development of novel trichinellosis treatments.
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