Evidence map›Paper›PMID 32576815›Full record

ArticleNature communications2020

Ultra-large chemical libraries for the discovery of high-affinity peptide binders.

Anthony J Quartararo, Zachary P Gates, Bente A Somsen, Nina Hartrampf, Xiyun Ye, Arisa Shimada, Yasuhiro Kajihara, Christian Ottmann, Bradley L Pentelute

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 143 citations in OpenAlex.

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  9. Universal Baseline forbioRxiv : the preprint server for biology · 2026
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  18. Self-assembled proteomimetic (SAP) with antibody-like binding from short PNA-peptide conjugates.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Anthony J QuartararoDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0003-4995-1424
Zachary P GatesDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Bente A SomsenLaboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, 5600, MB, Eindhoven, Netherlands.ORCID http://orcid.org/0000-0003-4862-3787
Nina HartrampfDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0003-0875-6390
Xiyun YeDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Arisa ShimadaDepartment of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka, 560-0043, Japan.
Yasuhiro KajiharaDepartment of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka, 560-0043, Japan.
Christian OttmannLaboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, 5600, MB, Eindhoven, Netherlands.
Bradley L PenteluteDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. blp@mit.edu.ORCID http://orcid.org/0000-0002-7242-801X
Massachusetts Institute of Technology · USEindhoven University of Technology · NLThe University of Osaka · JPBroad Institute · US

Funding

Interdepartmental Biotechnology Training ProgramT32GM008334 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WITTRUP, KARL DANE · 1989 to 2018
$15.2M
NIGMS NIH HHS T32 GM008334
6 · The paper itself

Abstract

High-diversity genetically-encoded combinatorial libraries (10

Indexed as

Peptide LibraryAmino AcidsAmino Acid SequenceAntibodies, MonoclonalAntibody AffinityCarrier ProteinsChromatography, LiquidCrystallography, X-RayDrug DesignDrug DiscoveryModels, MolecularPeptidesProto-Oncogene Proteins c-mdm2Small Molecule LibrariesAmino AcidsAntibodies, MonoclonalCarrier ProteinsPeptide LibraryPeptidesProto-Oncogene Proteins c-mdm2Small Molecule Libraries

Identifiers

PMID32576815
PMCPMC7311396
OpenAlexW3036771390

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.