ArticleAging2020
ADL-dependency, D-Dimers, LDH and absence of anticoagulation are independently associated with one-month mortality in older inpatients with Covid-19.
Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- The effects of hypertension on the prognosis of coronavirus disease 2019: a systematic review and meta-analysis on the interactions with age and antihypertensive treatment.Journal of hypertension · 2022Pooled it
- Pooled it
- Anticoagulation outcomes in hospitalized Covid-19 patients: A systematic review and meta-analysis of case-control and cohort studies.Reviews in medical virology · 2021Pooled it
- Effect of hydroxychloroquine with or without azithromycin on the mortality of coronavirus disease 2019 (COVID-19) patients: a systematic review and meta-analysis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2021Pooled it
- Discontinuity of social support among US adults with cognitive impairment before and after the confirmed diagnosis of dementia: a matched ambidirectional cohort study.BMC medicine · 2025Article
- The Impact of Therapeutic Plasma Exchange on Inflammatory Markers and Acute Phase Reactants in Patients with Severe SARS-CoV-2 Infection.Medicina (Kaunas, Lithuania) · 2023Review
- [Health-management experiences among older women living alone during the COVID-19 pandemic: A photovoice study].Journal of Korean gerontological nursing · 2023Article
- Trends in Gender and Racial/Ethnic Disparities in Physical Disability and Social Support Among U.S. Older Adults With Cognitive Impairment Living Alone, 2000-2018.Innovation in aging · 2023Article
- Using machine learning in prediction of ICU admission, mortality, and length of stay in the early stage of admission of COVID-19 patients.Annals of operations research · 2022Article
- Impact of serum lactate dehydrogenase on the short-term prognosis of COVID-19 with pre-existing cardiovascular diseases.Journal of cardiology · 2022Article
- Difficulty and help with activities of daily living among older adults living alone during the COVID-19 pandemic: a multi-country population-based study.BMC geriatrics · 2022Article
- Major coagulation disorders and parameters in COVID-19 patients.European journal of medical research · 2022Review
- Impact of pre-admission antithrombotic therapy on disease severity and mortality in patients hospitalized for COVID-19.Journal of thrombosis and thrombolysis · 2022Observational
- A Multimodal Approach for the Risk Prediction of Intensive Care and Mortality in Patients with COVID-19.Diagnostics (Basel, Switzerland) · 2021Article
- Clinical Management of Adult Patients with COVID-19 Outside Intensive Care Units: Guidelines from the Italian Society of Anti-Infective Therapy (SITA) and the Italian Society of Pulmonology (SIP).Infectious diseases and therapy · 2021Article
- High versus Standard Intensity of Thromboprophylaxis in Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2021Review
- Observational
- Predicting clinical outcomes among hospitalized COVID-19 patients using both local and published models.BMC medical informatics and decision making · 2021Review
- Role of combining anticoagulant and antiplatelet agents in COVID-19 treatment: a rapid review.Open heart · 2021Review
- Factors affecting mortality in geriatric patients hospitalized with COVID-19Turkish journal of medical sciences · 2021Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo assess factors associated with one-month mortality among older inpatients with Covid-19.
resultsThe mean age was 78 ± 7.8 years, 55.5% were men, CT scan lung damage was observed in 76% of the patients (mild 23%, moderate 38%, extensive 22%, and severe 7%). The mortality rate was 26%. Dependency/Activities of Daily Living (ADL) score ≤ 5/6, D-Dimers, LDH, and no anticoagulation by reference for curative were independently associated with one-month mortality. A score derived from the multivariate model showed good calibration and very good discrimination (Harrell's C index [95%CI] = 0.83 [0.79-0.87]).
conclusionADL-dependency, high serum levels of D-Dimers and LDH and the absence of anticoagulation were independently associated with one-month mortality among older inpatients with Covid-19.
methods108 consecutive older inpatients aged 65 and over with Covid-19 confirmed by RT-PCR and/or typical CT chest scan were prospectively included in a French single-centre cohort study from March to April 2020. A systematic geriatric assessment was performed. Covariates were lymphocyte count, serum levels of albumin, C-Reactive Protein, D-Dimers and Lactate Dehydrogenase (LDH), anticoagulation level, and exposure to the hydroxychloroquine and azithromycin combined therapy. Cox uni- and multivariate proportional-hazard regressions were performed to identify predictors of one-month mortality.
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